Ghrelin as a starvation signal

被引：8
作者：
Date, Yukari [1 ]
Kangawa, Kenji [2 ]
机构：
[1] Miyazaki Univ, Frontier Sci Res Ctr, Miyazaki 8891692, Japan
[2] Natl Cerebral & Cardiovasc Ctr, Res Inst, Osaka 5658565, Japan
来源：
OBESITY RESEARCH & CLINICAL PRACTICE | 2012年 / 6卷 / 04期
关键词：
Ghrelin; GHS-R; Feeding; Vagus nerve; GROWTH-HORMONE RELEASE; ACTIVATED PROTEIN-KINASE; GLUCAGON-LIKE PEPTIDE-1; DES-ACYL GHRELIN; FOOD-INTAKE; CIRCULATING GHRELIN; PRADER-WILLI; VAGAL NERVE; WEIGHT-LOSS; PITUITARY;
D O I：
10.1016/j.orcp.2012.08.195
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ghrelin, a gastrointestinal hormone, functions as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). It comprises 28 amino acids, of which the Ser-3 residue is post-translationally modified by the addition of octanoyl acid. Ghrelin stimulates feeding and the secretion of growth hormone; it is also thought to function in energy conservation. Here, we provide an overview of the discovery of ghrelin, its pathophysiological significance, and the mechanism of ghrelin-induced feeding. (C) 2012 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：E263 / E269
页数：7
相关论文
共 50 条
  • [1] Ghrelin: a metabolic signal affecting the reproductive system
    Lorenzi, Teresa
    Meli, Rosaria
    Marzioni, Daniela
    Morroni, Manrico
    Baragli, Alessandra
    Castellucci, Mario
    Gualillo, Oreste
    Muccioli, Giampiero
    CYTOKINE & GROWTH FACTOR REVIEWS, 2009, 20 (02) : 137 - 152
  • [2] Translational research of ghrelin
    Ueno, Hiroaki
    Shiiya, Tomomi
    Nakazato, Masamitsu
    PHYLOGENETIC ASPECTS OF NEUROPEPTIDES: FROM INVERTEBRATES TO HUMANS, 2010, 1200 : 120 - 127
  • [3] Ghrelin/ghrelin receptors
    Kaiya, Hiroyuki
    Kangawa, Kenji
    Miyazato, Mikiya
    JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2014, 52 (03) : T87 - T100
  • [4] Ghrelin and the Control of Energy Balance in Females
    Smith, Andrea
    Woodside, Barbara
    Abizaid, Alfonso
    FRONTIERS IN ENDOCRINOLOGY, 2022, 13
  • [5] Ghrelin and the heart
    Tokudome, Takeshi
    Otani, Kentaro
    Miyazato, Mikiya
    Kangawa, Kenji
    PEPTIDES, 2019, 111 : 42 - 46
  • [6] Ghrelin and Metabolic Disorders
    Ukkola, Olavi
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2009, 10 (01) : 2 - 7
  • [7] Ghrelin and eating disorders
    Atalayer, Deniz
    Gibson, Charlisa
    Konopacka, Alexandra
    Geliebter, Allan
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2013, 40 : 70 - 82
  • [8] A role of ghrelin in cancerogenesis
    Majchrzak, K.
    Szyszko, K.
    Pawlowski, K. M.
    Motyl, T.
    Krol, M.
    POLISH JOURNAL OF VETERINARY SCIENCES, 2012, 15 (01): : 189 - 197
  • [9] The role of ghrelin in weight-regulation disorders: Implications in clinical practice
    Solomou, Solomis
    Korbonits, Marta
    HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2014, 13 (04): : 458 - 475
  • [10] Structure, regulation and function of ghrelin
    Sato, Takahiro
    Nakamura, Yuki
    Shiimura, Yuki
    Ohgusu, Hideko
    Kangawa, Kenji
    Kojima, Masayasu
    JOURNAL OF BIOCHEMISTRY, 2012, 151 (02) : 119 - 128
12345