Cell Polarization and Cytokinesis in Budding Yeast

被引：229

作者：

Bi, Erfei ^{[1
]}

Park, Hay-Oak ^{[2
]}

机构：

[1] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[2] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

来源：

GENETICS | 2012年 / 191卷 / 02期

基金：

美国国家卫生研究院;

关键词：

BUD-SITE-SELECTION; GTP-BINDING PROTEIN; GUANINE-NUCLEOTIDE-EXCHANGE; GDP-DISSOCIATION INHIBITOR; SACCHAROMYCES-CEREVISIAE GENE; PHOSPHORYLATION-DEPENDENT REGULATION; SPINDLE POSITION CHECKPOINT; ALDRICH-SYNDROME PROTEIN; MAP KINASE PATHWAY; MYOSIN LIGHT-CHAIN;

D O I：

10.1534/genetics.111.132886

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for generating cell diversity during development. The budding yeast Saccharomyces cerevisiae reproduces by asymmetric cell division, and has thus served as an attractive model for unraveling the general principles of eukaryotic cell polarization and cytokinesis. Polarity development requires G-protein signaling, cytoskeletal polarization, and exocytosis, whereas cytokinesis requires concerted actions of a contractile actomyosin ring and targeted membrane deposition. In this chapter, we discuss the mechanics and spatial control of polarity development and cytokinesis, emphasizing the key concepts, mechanisms, and emerging questions in the field.

引用

页码：347 / 387

页数：41

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