Cell Polarization and Cytokinesis in Budding Yeast

被引：229

作者：

Bi, Erfei ^{[1
]}

Park, Hay-Oak ^{[2
]}

机构：

[1] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[2] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

来源：

GENETICS | 2012年 / 191卷 / 02期

基金：

美国国家卫生研究院;

关键词：

BUD-SITE-SELECTION; GTP-BINDING PROTEIN; GUANINE-NUCLEOTIDE-EXCHANGE; GDP-DISSOCIATION INHIBITOR; SACCHAROMYCES-CEREVISIAE GENE; PHOSPHORYLATION-DEPENDENT REGULATION; SPINDLE POSITION CHECKPOINT; ALDRICH-SYNDROME PROTEIN; MAP KINASE PATHWAY; MYOSIN LIGHT-CHAIN;

D O I：

10.1534/genetics.111.132886

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for generating cell diversity during development. The budding yeast Saccharomyces cerevisiae reproduces by asymmetric cell division, and has thus served as an attractive model for unraveling the general principles of eukaryotic cell polarization and cytokinesis. Polarity development requires G-protein signaling, cytoskeletal polarization, and exocytosis, whereas cytokinesis requires concerted actions of a contractile actomyosin ring and targeted membrane deposition. In this chapter, we discuss the mechanics and spatial control of polarity development and cytokinesis, emphasizing the key concepts, mechanisms, and emerging questions in the field.

引用

页码：347 / 387

页数：41

共 462 条

[21] Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae [J].

Asakura, T ;

Sasaki, T ;

Nagano, F ;

Satoh, A ;

Obaishi, H ;

Nishioka, H ;

Imamura, H ;

Hotta, K ;

Tanaka, K ;

Nakanishi, H ;

Takai, Y .

ONCOGENE, 1998, 16 (01) :121-130

[22] Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast [J].

Asano, Satoshi ;

Park, Jung-Eun ;

Yu, Li-Rong ;

Zhou, Ming ;

Sakchaisri, Krisada ;

Park, Chong J. ;

Kang, Young H. ;

Thorner, Jeremy ;

Veenstra, Timothy D. ;

Lee, Kyung S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (37) :27090-27098

[23] Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade [J].

Audhya, A ;

Emr, SD .

DEVELOPMENTAL CELL, 2002, 2 (05) :593-605

[24] High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A [J].

Ayscough, KR ;

Stryker, J ;

Pokala, N ;

Sanders, M ;

Crews, P ;

Drubin, DG .

JOURNAL OF CELL BIOLOGY, 1997, 137 (02) :399-416

[25] Comparative analysis of cytokinesis in buddina yeast, fission yeast and animal cells [J].

Balasubramanian, MK ;

Bi, EF ;

Glotzer, M .

CURRENT BIOLOGY, 2004, 14 (18) :R806-R818

[26] Cytokinesis: Placing and making the final cut [J].

Barr, Francis A. ;

Gruneberg, Ulrike .

CELL, 2007, 131 (05) :847-860

[27] USE OF A SCREEN FOR SYNTHETIC LETHAL AND MULTICOPY SUPPRESSEE MUTANTS TO IDENTIFY 2 NEW GENES INVOLVED IN MORPHOGENESIS IN SACCHAROMYCES-CEREVISIAE [J].

BENDER, A ;

PRINGLE, JR .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (03) :1295-1305

[28] GENETIC-EVIDENCE FOR THE ROLES OF THE BUD-SITE-SELECTION GENES BUD5 AND BUD2 IN CONTROL OF THE RSR1P (BUD1P) GTPASE IN YEAST [J].

BENDER, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :9926-9929

[29] MULTICOPY SUPPRESSION OF THE CDC24 BUDDING DEFECT IN YEAST BY CDC42 AND 3 NEWLY IDENTIFIED GENES INCLUDING THE RAS-RELATED GENE RSR1 [J].

BENDER, A ;

PRINGLE, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :9976-9980

[30] Two GTPase isoforms, ypt31p and ypt32p, are essential for Golgi function in yeast [J].

Benli, M ;

Doring, F ;

Robinson, DG ;

Yang, XP ;

Gallwitz, D .

EMBO JOURNAL, 1996, 15 (23) :6460-6475

← 1 2 3 4 5 6 7 8 9 10 →