Long-Term Effectiveness of Antiretroviral Therapy in China: An Observational Cohort Study from 2003-2014

被引:3
|
作者
Huang, Peng [1 ]
Tan, Jingguang [2 ]
Ma, Wenzhe [1 ]
Zheng, Hui [1 ]
Lu, Yan [2 ]
Wang, Ning [3 ]
Peng, Zhihang [1 ]
Yu, Rongbin [1 ]
机构
[1] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 211166, Jiangsu, Peoples R China
[2] Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Peoples R China
[3] Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing 102206, Peoples R China
来源
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2015年 / 12卷 / 08期
关键词
HIV; ART; mortality; observational cohort study; China; TREATMENT PROGRAM; HIV-INFECTION; MORTALITY; HAART; HIV/AIDS; DEATH; AIDS;
D O I
10.3390/ijerph120808762
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In order to assess the effectiveness of the Chinese government's expanded access program, a cohort study on all adult HIV patients in Shenzhen was conducted from December 2003 to February 2014 to estimate the effects of antiretroviral therapy (ART) on mortality, tuberculosis and CD4 cell counts. Marginal structural regression models adjusted for baseline and time-varying covariates. Of the 6897 patients enrolled and followed up for a maximum of 178 months, 44.92% received ART. Among patients who commenced receiving ART during the study, there were 98 deaths and 59 new tuberculosis diagnoses, while there were 410 deaths and 201 new tuberculosis diagnoses among those without ART. ART was associated with both lower mortality (hazard ratio [HR] = 0.18; 95% confidence interval [CI] = 0.11-0.27) and the presence of tuberculosis (HR = 0.27; 95% CI = 0.19-0.37). Each month of ART was associated with an average increase in CD4 cell count of 6.52 cells/mu L (95% CI = 6.08-7.12 cells/mu L). In conclusions, the effectiveness of ART provided by China government health services is the same as that in higher-income countries. Accounting to higher mortality rates from the delay of starting ART, faster expansion and timely imitation of ART are urgent.
引用
收藏
页码:8762 / 8772
页数:11
相关论文
共 50 条
  • [41] Long-term Outcomes of Cytomegalovirus Retinitis in the Era of Modern Antiretroviral Therapy Results from a United States Cohort
    Jabs, Douglas A.
    Ahuja, Alka
    Van Natta, Mark L.
    Lyon, Alice T.
    Yeh, Steven
    Danis, Ronald
    OPHTHALMOLOGY, 2015, 122 (07) : 1452 - 1463
  • [42] The safety of long-term bevacizumab use: Results from the Brite observational cohort study (OCS)
    Sugrue, M.
    Purdie, D.
    Chiruvolu, P.
    Berlin, J.
    Flynn, P.
    Grothey, A.
    Kabbinavar, F.
    Dong, W.
    Kozloff, M.
    ANNALS OF ONCOLOGY, 2008, 19 : 83 - 83
  • [43] The safety of long-term bevacizumab use: Results from the BRiTE observational cohort study (OCS)
    Purdie, D. M.
    Berlin, J. D.
    Flynn, P. J.
    Grothey, A.
    Kabbinavar, F. F.
    Kozloff, M. F.
    Dong, W.
    Sugrue, M. M.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [44] Effectiveness of combination antiretroviral therapy on survival and opportunistic infections in a developing world setting - An observational cohort study
    Corey, Daniel M.
    Kim, Hyung Woo
    Salazar, Raul
    Illescas, Ricardo
    Villena, Juan
    Gutierrez, Luis
    Sanchez, Jorge
    Tabet, Stephen R.
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2007, 44 (04) : 451 - 455
  • [45] Socioeconomic and geographical variation in general practitioner consultations for allergic rhinitis in England, 2003-2014: an observational study
    Todkill, Daniel
    Loveridge, Paul
    Elliot, Alex James
    Morbey, Roger
    de Lusignan, Simon
    Edeghere, Obaghe
    Smith, Gillian
    BMJ OPEN, 2017, 7 (08):
  • [46] MEASURING LONG-TERM THERAPEUTIC EFFECTIVENESS WITH OBSERVATIONAL DATA
    SUCH, C
    CRISWELL, L
    HENKE, C
    ARTHRITIS AND RHEUMATISM, 1995, 38 (09): : 147 - 147
  • [47] Long-Term Effectiveness of Vestibulectomy for the Treatment of Vulvodynia: A Retrospective Cohort Study
    Coryn, Nele
    Vergauwe, Bart
    Weyers, Steven
    Verstraelen, Hans
    JOURNAL OF LOWER GENITAL TRACT DISEASE, 2024, 28 (03) : 258 - 263
  • [48] Long-term effectiveness of recommended boosted protease inhibitor-based antiretroviral therapy in Europe
    Santos, J. R.
    Cozzi-Lepri, A.
    Phillips, A.
    De Wit, S.
    Pedersen, C.
    Reiss, P.
    Blaxhult, A.
    Lazzarin, A.
    Sluzhynska, M.
    Orkin, C.
    Duvivier, C.
    Bogner, J.
    Gargalianos-Kakolyris, P.
    Schmid, P.
    Hassoun, G.
    Khromova, I.
    Beniowski, M.
    Hadziosmanovic, V.
    Sedlacek, D.
    Paredes, R.
    Lundgren, J. D.
    HIV MEDICINE, 2018, 19 (05) : 324 - 338
  • [49] Effect of AIDS-defining events at initiation of antiretroviral therapy on long-term mortality of HIV/AIDS patients in Southwestern China: a retrospective cohort study
    Yunxuan Huang
    Oulu Zhou
    Zhigang Zheng
    Yuexiang Xu
    Yi Shao
    Chunwei Qin
    Fengxiang Qin
    Jingzhen Lai
    Huifang Liu
    Rongfeng Chen
    Li Ye
    Hao Liang
    Xionglin Qin
    Junjun Jiang
    AIDS Research and Therapy, 17
  • [50] Effect of AIDS-defining events at initiation of antiretroviral therapy on long-term mortality of HIV/AIDS patients in Southwestern China: a retrospective cohort study
    Huang, Yunxuan
    Zhou, Oulu
    Zheng, Zhigang
    Xu, Yuexiang
    Shao, Yi
    Qin, Chunwei
    Qin, Fengxiang
    Lai, Jingzhen
    Liu, Huifang
    Chen, Rongfeng
    Ye, Li
    Liang, Hao
    Qin, Xionglin
    Jiang, Junjun
    AIDS RESEARCH AND THERAPY, 2020, 17 (01)