A Rapid One-Pot Ugi Reaction Based Route to Novel Imidazole-Fused Benzodiazepinones

被引：9

作者：

Bhattacharya, Debleena ^{[1
]}

Mitra, Sudipta ^{[1
]}

Chattopadhyay, Partha ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Biol, Dept Chem, Kolkata 700032, India

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 15期

关键词：

multicomponent reactions; heterocycles; fused-ring systems; isocyanides; imidazoles; rearrangements; TANDEM ONE-POT; MULTICOMPONENT REACTIONS; HIGH-AFFINITY; ISOCYANIDE; DERIVATIVES; RECEPTOR; PERSPECTIVE; INHIBITORS;

D O I：

10.1055/s-0034-1379916

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and efficient synthetic approach has been developed for the synthesis of a variety of imidazole-fused benzodiazepinones. It is based on a Ugi multicomponent reaction strategy and uses various isocyanides to generate the key intermediates for a Mumm rearrangement process. The method is suitable for rapid syntheses of fused azaheterocycles of pharmacological interest.

引用

页码：2294 / 2298

页数：5