A Rapid One-Pot Ugi Reaction Based Route to Novel Imidazole-Fused Benzodiazepinones

被引：9
作者：
Bhattacharya, Debleena [1 ]
Mitra, Sudipta [1 ]
Chattopadhyay, Partha [1 ]
机构：
[1] CSIR Indian Inst Chem Biol, Dept Chem, Kolkata 700032, India
来源：
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 15期
关键词：
multicomponent reactions; heterocycles; fused-ring systems; isocyanides; imidazoles; rearrangements; TANDEM ONE-POT; MULTICOMPONENT REACTIONS; HIGH-AFFINITY; ISOCYANIDE; DERIVATIVES; RECEPTOR; PERSPECTIVE; INHIBITORS;
D O I：
10.1055/s-0034-1379916
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A short and efficient synthetic approach has been developed for the synthesis of a variety of imidazole-fused benzodiazepinones. It is based on a Ugi multicomponent reaction strategy and uses various isocyanides to generate the key intermediates for a Mumm rearrangement process. The method is suitable for rapid syntheses of fused azaheterocycles of pharmacological interest.
引用
收藏
页码：2294 / 2298
页数：5
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