The pedunculopontine nucleus and movement disorders: Anatomy and the role for deep brain stimulation

被引：43
作者：
Hamani, Clement [1 ]
Stone, Scellig [1 ]
Laxton, Adrian [1 ]
Lozano, Andres M. [1 ]
机构：
[1] Univ Toronto, Div Neurosurg, Dept Surg, Toronto Western Hosp,Res Inst, Toronto, ON M5T 2S8, Canada
来源：
PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷
基金：
英国医学研究理事会;
关键词：
pedunculopontine nucleus; Parkinson's disease; surgery; deep brain stimulation; gait; postural instability; axial symptoms;
D O I：
10.1016/S1353-8020(08)70016-6
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The pedunculopontine nucleus (PPN) is a brainstem locomotive center that also processes sensory and behavioral information. Through its connections with basal ganglia structures and the spinal cord, the PPN may play a role in axial motor symptoms in Parkinson's disease (PD). We review the anatomical features of the PPN, its role in motor control, and its potential role as a target for PD surgery, including the results of recently published clinical studies. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：S276 / S280
页数：5
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