Particulate transepithelial drug carriers: barriers and functional polymers

被引：14

作者：

Babiuch, Krzysztof ^{[1
,2
]}

Gottschaldt, Michael ^{[1
,2
]}

Werz, Oliver ^{[2
,3
]}

Schubert, Ulrich S. ^{[1
,2
,4
]}

机构：

[1] Univ Jena, Lab Organ & Macromol Chem IOMC, D-07743 Jena, Germany

[2] Univ Jena, Jena Ctr Soft Matter, D-07743 Jena, Germany

[3] Univ Jena, Inst Pharm, Chair Pharmaceut Med Chem, D-07743 Jena, Germany

[4] Dutch Polymer Inst, NL-5612 AB Eindhoven, Netherlands

来源：

RSC ADVANCES | 2012年 / 2卷 / 28期

关键词：

POLYACRYL STARCH MICROPARTICLES; ANTIGEN-PRESENTING CELLS; POLY(GAMMA-GLUTAMIC ACID) NANOPARTICLES; INTESTINAL EPITHELIAL-CELLS; MUCOSAL IMMUNE-RESPONSES; TIGHT JUNCTION PROTEINS; IN-VITRO EVALUATION; DENDRITIC CELLS; DELIVERY-SYSTEMS; PLGA MICROSPHERES;

D O I：

10.1039/c2ra20726e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review may serve as a compilation of helpful guidelines for design, synthesis, formulation, and in vitro, ex vivo as well as in vivo evaluation of particulate drug delivery systems that cross epithelial barriers. It provides both chemist and biologist with a comprehensive overview of complex anatomorphological features encountered by intranasally, pulmonary and orally administered particles. In addition, the materials (structures, modifications, formulations, and activity) used in transepithelial delivery are discussed. It covers the biological as well as physicochemical aspects crucial for the successful development of particulate drug carriers and methods for their application.

引用

页码：10427 / 10465

页数：39

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