PEG-Mediated Catalyst-Free Expeditious Synthesis of Polysubstituted Anilines and Benzenes via the Reaction of Malononitrile and β-Ketoester Derivatives in the Presence of Activated Acetylenes

被引：6

作者：

Piltan, Mohammad ^{[1
]}

Moradi, Loghman ^{[2
]}

Salimi, Hiwa ^{[1
]}

Zargoosh, Kiomars ^{[3
]}

Zarei, Seyed Amir ^{[1
]}

机构：

[1] Islamic Azad Univ, Sanandaj Branch, Dept Chem, Sanandaj, Iran

[2] Univ Kurdistan, Fac Sci, Dept Chem, Sanandaj, Iran

[3] Isfahan Univ Technol, Dept Chem, Esfahan, Iran

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2012年 / 15卷 / 07期

关键词：

Activated acetylenes; functionalized anilines and benzenes; malononitrile; PEG; beta-ketoester; EFFICIENT SYNTHESIS; ARYL HALIDES; AMINATION; ARENES;

D O I：

10.2174/138620712801619195

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(ethylene glycol) (PEG) has been used as a sustainable, non-volatile, and environmentally friendly reaction solvent for synthesis of functionalized anilines and benzenes via the reaction of malononitrile and beta-ketoester derivatives in the presence of activated acetylenes at 80 degrees C. No additional solvent and catalyst are required. [GRAPHICS] .

引用

页码：571 / 575

页数：5

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