FATHEAD MINNOW (PIMEPHALES PROMELAS RAFINESQUE) EXPOSURE TO THREE NOVEL BROMINATED FLAME RETARDANTS IN OUTDOOR MESOCOSMS: BIOACCUMULATION AND BIOTRANSFORMATION

被引：27
作者：
de Jourdan, Benjamin P. [1 ]
Hanson, Mark L. [2 ]
Muir, Derek C. G. [3 ]
Solomon, Keith R. [1 ]
机构：
[1] Univ Guelph, Guelph, ON N1G 2W1, Canada
[2] Univ Manitoba, Winnipeg, MB, Canada
[3] Environm Canada, Aquat Contaminants Res Div, Burlington, ON L7R 4A6, Canada
来源：
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2014年 / 33卷 / 05期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Bioaccumulation; Biotransformation; Flame retardant; BTBPE; TBBAPA-BDBPE; BZ-54; DECABROMODIPHENYL ETHER BDE-209; POLYBROMINATED DIPHENYL ETHERS; TROUT SALVELINUS-NAMAYCUSH; JUVENILE RAINBOW-TROUT; ZEBRAFISH DANIO-RERIO; IN-VITRO; FOOD-WEB; DIETARY EXPOSURE; FIREMASTER(R) BZ-54; METABOLISM;
D O I：
10.1002/etc.2541
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The phaseout of polybrominated diphenyl ethers (PBDEs) has prompted the search for appropriate substitutes. These substitutes, referred to as novel brominated flame retardants (NBFRs), are poorly characterized in terms of their persistence, bioaccumulation, and toxicity. The authors assessed the bioaccumulation potential of 3 non-PBDE brominated flame retardants: 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), tetrabromobisphenol A bis(2,3-dibromopropylether) (TBBPA-BDBPE), and BZ-54, a mixture of bis(2-ethylhexyl)tetrabromophthalate) (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB). Replicate outdoor aquatic mesocosms were treated individually at concentrations designed to give a maximum load of 500ng/g of flame retardant in the upper 5cm of the sediment. Caged fathead minnows (Pimephales promelas, 24 fish per replicate) were introduced to each mesocosm and acclimated for 10 d prior to exposure. The exposure period was 42 d, followed by 28 d of depuration after transfer to a control mesocosm, during which physical, reproductive, and biochemical end points were examined. Tissue samples were taken to measure the accumulation, depuration, and biotransformation of NBFRs. Fathead minnows were observed to accumulate, after growth adjustment, BTBPE (16-4203ng/g lipid) and TBBPA-BDBPE (>1000ng/g lipid) but with a lack of consistent accumulation observed for EH-TBB and BEH-TEBP. However, limited biologically meaningful or consistent responses were observed in the monitored physical, reproductive, and biochemical parameters. Fathead minnows from each treatment exhibited several brominated transformation products. The authors conclude that these NBFRs have the potential to be bioaccumulative and persistent in vivo and, therefore, warrant further study of physiological effects linked to chronic, sublethal responses. Environ Toxicol Chem 2014;33:1148-1155. (c) 2014 SETAC
引用
收藏
页码：1148 / 1155
页数：8
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