A Photostable AIEgen for Specific and Real-time Monitoring of Lysosomal Processes

被引：14

作者：

Zhang, Weijie ^{[1
,2
,4
,5
]}

Zhou, Fan ^{[3
]}

Wang, Zhiming ^{[1
,3
]}

Zhao, Zujin ^{[3
]}

Qin, Anjun ^{[3
]}

Tang, Ben Zhong ^{[1
,3
,4
,5
]}

机构：

[1] HKUST Shenzhen Res Inst, Shenzhen 518057, Peoples R China

[2] Soochow Univ, Urinary Surg, Affiliated Hosp 1, Pinghai Rd, Suzhou 215006, Peoples R China

[3] South China Univ Technol, Ctr Aggregat Induced Emiss, State Key Lab Luminescent Mat & Devices, Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China

[4] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Clear Water Bay, Hong Kong, Peoples R China

[5] Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2019年 / 14卷 / 10期

基金：

中国国家自然科学基金;

关键词：

aggregation-induced emission; autophagy; lysosomes; monitoring; phagocytosis of macromolecules; AGGREGATION-INDUCED EMISSION; PROBE; AUTOPHAGY; RED; ACID;

D O I：

10.1002/asia.201801676

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lysosomes are recognized as advanced organelles involved in many cellular processes and are also considered as crucial regulators of cell homeostasis. The current strategies for monitoring activities of lysosomes exhibit some limitations. Herein, we synthesized a novel fluorescent probe named 2M-DPAS with AIE characteristics, which was proved to have significant advantages of good biocompatibility, high selectivity, bright emission and excellent photostability. Based on those, 2M-DPAS can be used to continuously monitor the dynamic changes of lysosomes, including autophagy and mitophagy, as well as to track the process of endocytosis of macromolecules in lysosomes, which are of benefit to better know about the lysosomes-related diseases.

引用

页码：1662 / 1666

页数：5