BIOnic Liquids: Imidazolium-based Ionic Liquids with Antimicrobial Activity

被引：35
作者：
Postleb, Frank [1 ]
Stefanik, Danuta [2 ]
Seifert, Harald [2 ]
Giernoth, Ralf [1 ]
机构：
[1] Univ Cologne, Dept Chem, D-50939 Cologne, Germany
[2] Univ Cologne, Inst Med Mikrobiol Immunol & Hyg, D-50935 Cologne, Germany
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2013年 / 68卷 / 10期
关键词：
Ionic Liquids; Active Pharmaceutical Ingredients (API); Imidazolium Salts; Antibiotics; Antimicrobials; Analgesics; BIOLOGICAL EVALUATION;
D O I：
10.5560/ZNB.2013-3150
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We have synthesized twelve new ionic liquids composed of an imidazolium-based cation in combination with an anion that shows antiobiotic or analgesic activity. These "BIOnic Liquids" have been tested towards their antibiotic activity in a standardized microbiological assay. A surprizingly large number of compounds shows high activity towards a set of bacteria which cannot be explained as simple cumulative effects. The general concept opens up completely new possibilities for the future development of pharmaceutically active compounds.
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页码：1123 / 1128
页数：6
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