Synthesis and In Vivo Anticonvulsant Screening of Coumarin Incorporated Schiff Bases of 1,3,4-Oxadiazoles

被引：13

作者：

Siddiqui, Nadeem ^{[1
]}

Bhat, Mashooq A. ^{[1
]}

Khan, Suroor A. ^{[1
]}

Ahsan, Waquar ^{[1
]}

Alam, M. Shamsher ^{[1
]}

机构：

[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2008年 / 55卷 / 06期

关键词：

Coumarin; MES test; 1,3,4-Oxadiazoles; Schiff bases;

D O I：

10.1002/jccs.200800199

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of coumarin incorporated Schiff bases of 1,3,4-oxadiazoles (1-18) was synthesized. The structures of the synthesized compounds were confirmed on the basis of spectral data and elemental analysis. The anticonvulsant and neurotoxicity was studied by maximal electroshock seizure (MES) and rotorod method, respectively. A majority of the compounds were active in MES test. All the compounds were less neurotoxic than the standard drug phenytoin.

引用

页码：1326 / 1331

页数：6

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