Synthesis of potent sigma-1 receptor ligands via fragmentation of dextromethorphan

被引：0
|
作者：
Arrington, MP [1 ]
Brown, C [1 ]
Schwartz, CE [1 ]
机构：
[1] UCB Res Inc, Cambridge, MA 02139 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 07期
关键词：
D O I：
10.1016/j.bmcl.2003.12.105
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Treatment of dextromethorphan 1 with various alkylating agents followed by base treatment led to Hoffman-type elimination reactions to produce a series of tricyclic derivatives, 6. These derivatives were characterized in vitro as sigma-1 receptor ligands. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1807 / 1809
页数：3
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