Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?

被引：549
作者：
Munoz-Canoves, Pura [1 ]
Scheele, Camilla [2 ,3 ]
Pedersen, Bente K. [2 ,3 ]
Serrano, Antonio L. [1 ]
机构：
[1] Pompeu Fabra Univ UPF, ICREA, Dept Expt & Hlth Sci, Cell Biol Grp,CIBER Neurodegenerat Dis CIBERNED, Barcelona 08003, Spain
[2] Univ Copenhagen, Rigshosp, Ctr Inflammat & Metab, Dept Infect Dis, DK-1168 Copenhagen, Denmark
[3] Univ Copenhagen, Rigshosp, CMRC, DK-1168 Copenhagen, Denmark
来源：
FEBS JOURNAL | 2013年 / 280卷 / 17期
基金：
新加坡国家研究基金会; 欧盟第七框架计划;
关键词：
growth; atrophy; IL-6; inflammation; metabolism; myogenesis; myokine; regeneration; satellite cell; signaling pathway; skeletal muscle; LEUKEMIA INHIBITORY FACTOR; ACTIVATED PROTEIN-KINASE; EXPERIMENTAL CANCER CACHEXIA; MESSENGER-RNA EXPRESSION; KAPPA-B ACTIVITY; GROWTH-FACTOR-I; TNF-ALPHA; TRANSGENIC MICE; MYOGENIC DIFFERENTIATION; COLON-26; ADENOCARCINOMA;
D O I：
10.1111/febs.12338
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. Muscle is also an important target of the cytokine. IL-6 signaling has been associated with stimulation of hypertrophic muscle growth and myogenesis through regulation of the proliferative capacity of muscle stem cells. Additional beneficial effects of IL-6 include regulation of energy metabolism, which is related to the capacity of actively contracting muscle to synthesize and release IL-6. Paradoxically, deleterious actions for IL-6 have also been proposed, such as promotion of atrophy and muscle wasting. We review the current evidence for these apparently contradictory effects, the mechanisms involved and discuss their possible biological implications.
引用
收藏
页码：4131 / 4148
页数：18
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