Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia

被引：20

作者：

Holmes, N. E. ^{[1
,2
]}

Turnidge, J. D. ^{[3
,4
]}

Munckhof, W. J. ^{[5
,6
]}

Robinson, J. O. ^{[7
]}

Korman, T. M. ^{[8
,9
]}

O'Sullivan, M. V. N. ^{[10
,11
]}

Anderson, T. L. ^{[12
,13
]}

Roberts, S. A. ^{[14
]}

Warren, S. J. C. ^{[12
,13
]}

Gao, W. ^{[1
,15
]}

Johnson, P. D. R. ^{[1
,2
,16
]}

Howden, B. P. ^{[1
,15
,16
,17
]}

机构：

[1] Austin Hlth, Dept Infect Dis, Austin Ctr Infect Res, Heidelberg, Vic 3084, Australia

[2] Univ Melbourne, Dept Med, Parkville, Vic 3052, Australia

[3] Womens & Childrens Hosp, SA Pathol, Adelaide, SA, Australia

[4] Univ Adelaide, Dept Paediat Pathol & Mol & Biomed Sci, Adelaide, SA, Australia

[5] Princess Alexandra Hosp, Infect Management Serv, Wolloongabba, Qld, Australia

[6] Univ Queensland, Dept Med, St Lucia, Qld 4067, Australia

[7] Royal Perth Hosp, Dept Infect Dis, Perth, WA 6001, Australia

[8] Southern Hlth, Dept Infect Dis, Clayton, Vic, Australia

[9] Monash Univ, Dept Med, Clayton, Vic, Australia

[10] Westmead Hosp, Ctr Infect Dis & Microbiol, Westmead, NSW 2145, Australia

[11] Univ Sydney, Dept Med, Sydney, NSW 2006, Australia

[12] Royal Hobart Hosp, Dept Infect Dis, Hobart, Tas, Australia

[13] Univ Tasmania, Dept Med, Hobart, Tas, Australia

[14] Auckland Dist Hlth Board, Auckland, New Zealand

[15] Austin Hlth, Dept Microbiol, Heidelberg, Vic 3084, Australia

[16] Monash Univ, Dept Microbiol, Clayton, Vic 3168, Australia

[17] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2013年 / 19卷 / 12期

基金：

英国医学研究理事会;

关键词：

Bacteraemia; comorbidity; mortality; Staphylococcus aureus; vancomycin minimum inhibitory concentration; NOT-RESUSCITATE ORDERS; RISK-FACTORS; OUTCOMES; ASSOCIATIONS; ENDOCARDITIS; INFECTION; GENOTYPE;

D O I：

10.1111/1469-0691.12168

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We reported an association between elevated vancomycin MIC and 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB), including patients with methicillin-susceptible S.aureus (MSSA) treated with flucloxacillin. A detailed analysis of comorbidities and disease severity scores in the same cohort of patients was performed to ascertain if unknown clinical parameters may have influenced these results. The association between elevated vancomycin MIC and 30-day mortality in SAB remained significant (p0.001) on multivariable logistic regression analysis even when accounting for clinical factors. In addition, the association persisted when restricting analysis to patients with MSSA bacteraemia treated with flucloxacillin. This suggests that elevated vancomycin MIC is associated with but not causally linked to an organism factor that is responsible for increased mortality.

引用

页码：1163 / 1168

页数：6

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