Induction chemotherapy in head and neck cancers: Results and controversies

被引：60

作者：

Gau, Max ^{[1
]}

Karabajakian, Andy ^{[1
]}

Reverdy, Thibaut ^{[1
]}

Neidhardt, Eve-Marie ^{[1
]}

Fayette, Jerome ^{[1
]}

机构：

[1] Lyon I Univ, Ctr Lutte Canc Leon Berard, Lyon, France

来源：

ORAL ONCOLOGY | 2019年 / 95卷

关键词：

Head and neck cancer; Induction chemotherapy; Locally advanced; Chemoradiation; Organ preservation; SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; PHASE-II; CONCURRENT CHEMORADIOTHERAPY; ORGAN-PRESERVATION; RANDOMIZED-TRIAL; ADVANCED LARYNX; CISPLATIN; DOCETAXEL; CETUXIMAB;

D O I：

10.1016/j.oraloncology.2019.06.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Standard treatment for locally advanced head and neck squamous cell carcinoma (LAHNSCC) consists mainly of concurrent chemoradiation (CCR) but induction chemotherapy (IC) by docetaxel-cisplatin-fluorouracil (TPF), followed by CCR, is a strong option. Comparative trials suggest that IC and CCR are equivalent, and some trials suggest superiority of IC, whereas none shows inferiority. IC might have less interest in oropharyngeal cancer (more often linked to HPV infection). When functional laryngeal preservation is the patient's priority, essays strongly suggest that IC is the best treatment. There is little data about a less toxic regimen of IC, but several schemes are promising and need to be developed. An early selection of responders to IC by metabolic imaging must be considered. Intensification attempts with cetuximab were too toxic and unsafe, but trials with immunotherapy are ongoing to enhance TPF efficacy. After IC, CCR either with cetuximab or cisplatin seems to be equally effective.

引用

页码：164 / 169

页数：6

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