IMMUNOLOGY Caspase target drives pyroptosis

被引：169

作者：

Broz, Petr ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

NATURE | 2015年 / 526卷 / 7575期

关键词：

INFLAMMATORY CASPASES; ROCK-I; ACTIVATION; CLEAVAGE;

D O I：

10.1038/nature15632

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inflammatory caspase proteins help to control pathogen replication by triggering pyroptotic cell death. It now emerges that cleavage of the caspase substrate gasdermin D is sufficient to induce pyroptosis. See Articles p.660 & p.666

引用

页码：642 / 643

页数：2

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