IMMUNOLOGY Caspase target drives pyroptosis

被引：154
作者：
Broz, Petr [1 ]
机构：
[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland
来源：
NATURE | 2015年 / 526卷 / 7575期
关键词：
INFLAMMATORY CASPASES; ROCK-I; ACTIVATION; CLEAVAGE;
D O I：
10.1038/nature15632
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Inflammatory caspase proteins help to control pathogen replication by triggering pyroptotic cell death. It now emerges that cleavage of the caspase substrate gasdermin D is sufficient to induce pyroptosis. See Articles p.660 & p.666
引用
收藏
页码：642 / 643
页数：2
相关论文
共 12 条
  • [1] Inflammatory Stimuli Regulate Caspase Substrate Profiles
    Agard, Nicholas J.
    Maltby, David
    Wells, James A.
    [J]. MOLECULAR & CELLULAR PROTEOMICS, 2010, 9 (05) : 880 - 893
  • [2] Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
    Cai, Zhenyu
    Jitkaew, Siriporn
    Zhao, Jie
    Chiang, Hsueh-Cheng
    Choksi, Swati
    Liu, Jie
    Ward, Yvona
    Wu, Ling-gang
    Liu, Zheng-Gang
    [J]. NATURE CELL BIOLOGY, 2014, 16 (01) : 55 - +
  • [3] Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
    Coleman, ML
    Sahai, EA
    Yeo, M
    Bosch, M
    Dewar, A
    Olson, MF
    [J]. NATURE CELL BIOLOGY, 2001, 3 (04) : 339 - 345
  • [4] Pro-inflammatory programmed cell death
    Cookson, BT
    Brennan, MA
    [J]. TRENDS IN MICROBIOLOGY, 2001, 9 (03) : 113 - 114
  • [5] Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
    Kayagaki, Nobuhiko
    Stowe, Irma B.
    Lee, Bettina L.
    O'Rourke, Karen
    Anderson, Keith
    Warming, Soren
    Cuellar, Trinna
    Haley, Benjamin
    Roose-Girma, Merone
    Phung, Qui T.
    Liu, Peter S.
    Lill, Jennie R.
    Li, Hong
    Wu, Jiansheng
    Kummerfeld, Sarah
    Zhang, Juan
    Lee, Wyne P.
    Snipas, Scott J.
    Salvesen, Guy S.
    Morris, Lucy X.
    Fitzgerald, Linda
    Zhang, Yafei
    Bertram, Edward M.
    Goodnow, Christopher C.
    Dixit, Vishva M.
    [J]. NATURE, 2015, 526 (7575) : 666 - 671
  • [6] The inflammasome:: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
    Martinon, F
    Burns, K
    Tschopp, J
    [J]. MOLECULAR CELL, 2002, 10 (02) : 417 - 426
  • [7] A NOVEL SECRETORY PATHWAY FOR INTERLEUKIN-1-BETA, A PROTEIN LACKING A SIGNAL SEQUENCE
    RUBARTELLI, A
    COZZOLINO, F
    TALIO, M
    SITIA, R
    [J]. EMBO JOURNAL, 1990, 9 (05) : 1503 - 1510
  • [8] Delineating Immune-Mediated Mechanisms Underlying Hair Follicle Destruction in the Mouse Mutant Defolliculated
    Ruge, Fiona
    Glavini, Aikaterini
    Gallimore, Awen M.
    Richards, Hannah E.
    Thomas, Christopher P.
    O'Donnell, Valerie B.
    Philpott, Michael P.
    Porter, Rebecca M.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (03) : 572 - 579
  • [9] Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
    Sebbagh, M
    Renvoize, C
    Hamelin, J
    Riché, N
    Bertoglio, J
    Bréard, J
    [J]. NATURE CELL BIOLOGY, 2001, 3 (04) : 346 - 352
  • [10] Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
    Segawa, Katsumori
    Kurata, Sachiko
    Yanagihashi, Yuichi
    Brummelkamp, Thijn R.
    Matsuda, Fumihiko
    Nagata, Shigekazu
    [J]. SCIENCE, 2014, 344 (6188) : 1164 - 1168
12