An anti-viral peptide derived from the preS1 surface protein of hepatitis B virus

被引：17

作者：

Kim, Do-Hyoung ^{[1
]}

Ni, Yi ^{[2
]}

Lee, Si-Hyung ^{[1
]}

Urban, Stephan ^{[2
]}

Han, Kyou-Hoon ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Div Mol Therapeut, Mol Canc Res Ctr, Taejon 305806, South Korea

[2] Heidelberg Univ, Dept Mol Virol, Otto Meyerhof Zentrum, D-69120 Heidelberg, Germany

来源：

BMB REPORTS | 2008年 / 41卷 / 09期

关键词：

hepatitis B virus (HBV); intrinsically unstructured protein (IUP); lipo-peptides; local pre-structured motif; nuclear magnetic resonance (Nmr); preS1;

D O I：

10.5483/BMBRep.2008.41.9.640

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The preS1 surface protein of the hepatitis B virus (HBV) is a key factor involved in initial viral entry into hepatocytes. It has been long postulated that an anti-HBV effect should be achievable using peptide fragments of the preS1. Recent reports demonstrated that several preS1-derived lipo-peptides in genotype D HBV exhibit nano to picomolar inhibitory activity against HBV infection. In this study, an acylated analog of a preS1 fragment, a 21-residue lipo-peptide (named 7524 BVS7) with a sequence of palmitoyl-GMGTNLSVPNPLGFFPDHQLDC-NH2, from genotype C HBV was produced base upon a previous structural study and was shown potently inhibits HBV infection with an IC50 of approximate to 20 nM.

引用

页码：640 / 644

页数：5

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