Regioselectivity in the Sonogashira coupling of 4,6-dichloro-2-pyrone

被引：43
作者：
Fairlamb, IJS [1 ]
O'Brien, CT
Lin, ZY
Lam, KC
机构：
[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England
[2] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 07期
关键词：
D O I：
10.1039/b518232h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Sonogashira cross-coupling of 4,6-dichloro-2-pyrone with terminal acetylenes proceeds in good yields and high regioselectivity for the 6-position; dibenzylidene acetone (dba) type ligands play a non-innocent role in reactions mediated by Pd(dba)(2)/PPh3; theoretical studies indicate that C-6 oxidative addition is favoured both kinetically and thermodynamically.
引用
收藏
页码：1213 / 1216
页数：4
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