[3] Harvard Univ, Sch Med, Harvard Pilgrim Hlth Care, Boston, MA USA
[4] GlaxoSmithKline, Res Triangle Pk, NC USA
来源:
PRIMARY CARE RESPIRATORY JOURNAL
|
2010年
/
19卷
/
02期
关键词:
COPD;
pneumonia;
corticosteroids;
beta-agonists;
D O I:
10.4104/pcrj.2009.00072
中图分类号:
R1 [预防医学、卫生学];
学科分类号:
1004 ;
120402 ;
摘要:
Aim: To assess the risk of pneumonia among COPD patients using salmeterol/fluticasone propionate combination inhalers (SFC), inhaled corticosteroids (ICS), or long-acting beta-agonists (LABA), alone or in combination, compared to those using only short-acting bronchodilators (SABD). Method: The study population comprised 5245 individuals using inhaled treatment for COPD, identified from the databases of three large regional managed care organisations from different parts of the USA. Longitudinally-collected administrative data were obtained on their clinical histories and treatments. Nested case-control methods were used to calculate adjusted odds ratios (OR) for the risk of pneumonia while on therapy. Results: 2154 patients had at least one diagnosed case of pneumonia between 1st September 2001 and 31st August 2003. Relative to SABD, the only treatment associated with a non-significant increased risk of pneumonia was ICS used alone (OR=1.29; 95%CI: 0.96-1.73; p=0.09). Users of LABA alone (OR=0.92; 95 /0CI: 0.69-1.22) or SFC (OR=1.03; 95%CI: 0.74-1.42) had no increased risk for pneumonia relative to SABD. Advanced age and severity of lung disease were strongly associated with increased risk for pneumonia. Conclusion: Treatment with ICS or an ICS/LABA combination inhaler was not associated with a significantly increased risk of developing pneumonia. 2010 Primary Care Respiratory Society UK. All rights reserved. D Mapel et al. Prim Care Resp J 2010; 19(2): 109-117 doi:10.4104/pcrj.2009.00072
机构:
Konkuk Univ, Konkuk Univ Hosp, Sch Med, Div Pulm Allergy & Crit Care Med,Dept Internal Med, Seoul, South KoreaCatholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Div Pulm & Crit Care Med,Dept Internal Med, Seoul, South Korea
Kim, Youlim
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h-index:
机构:
Hwang, Yong Il
Yoo, Kwang Ha
论文数: 0引用数: 0
h-index: 0
机构:
Konkuk Univ, Konkuk Univ Hosp, Sch Med, Div Pulm Allergy & Crit Care Med,Dept Internal Med, Seoul, South KoreaCatholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Div Pulm & Crit Care Med,Dept Internal Med, Seoul, South Korea
Yoo, Kwang Ha
Lee, So Eun
论文数: 0引用数: 0
h-index: 0
机构:
Boehringer Ingelheim GmbH & Co KG, Med Affairs, Seoul, South KoreaCatholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Div Pulm & Crit Care Med,Dept Internal Med, Seoul, South Korea
Lee, So Eun
Jung, Kyung Yoon
论文数: 0引用数: 0
h-index: 0
机构:
Boehringer Ingelheim GmbH & Co KG, Med Affairs, Seoul, South KoreaCatholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Div Pulm & Crit Care Med,Dept Internal Med, Seoul, South Korea
Jung, Kyung Yoon
Lee, Doik
论文数: 0引用数: 0
h-index: 0
机构:
IQVIA, Real World Solut, Seoul, South KoreaCatholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Div Pulm & Crit Care Med,Dept Internal Med, Seoul, South Korea
Lee, Doik
Park, Yong Bum
论文数: 0引用数: 0
h-index: 0
机构:
Hallym Univ, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Kangdong Sacred Heart Hosp, Seoul, South KoreaCatholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Div Pulm & Crit Care Med,Dept Internal Med, Seoul, South Korea
机构:
Fu Jen Catholic Univ, Cardinal Tien Hosp, Dept Internal Med, New Taipei, Taiwan
Fu Jen Catholic Univ, Sch Med, Coll Med, New Taipei, Taiwan
Cardinal Tien Hosp, New Taipei, TaiwanFu Jen Catholic Univ, Cardinal Tien Hosp, Dept Internal Med, New Taipei, Taiwan
Wang, Cheng-Yi
Lin, You Shuei
论文数: 0引用数: 0
h-index: 0
机构:
Taipei Med Univ, Coll Med, Sch Med, Dept Physiol, Taipei, TaiwanFu Jen Catholic Univ, Cardinal Tien Hosp, Dept Internal Med, New Taipei, Taiwan
Lin, You Shuei
Wang, Ya-Hui
论文数: 0引用数: 0
h-index: 0
机构:
Fu Jen Catholic Univ, Sch Med, Coll Med, New Taipei, Taiwan
Fu Jen Catholic Univ, Cardinal Tien Hosp, Med Res Ctr, New Taipei, TaiwanFu Jen Catholic Univ, Cardinal Tien Hosp, Dept Internal Med, New Taipei, Taiwan
Wang, Ya-Hui
Lai, Chih-Cheng
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Vet Gen Hosp, Dept Internal Med, Tainan Branch, Tainan, TaiwanFu Jen Catholic Univ, Cardinal Tien Hosp, Dept Internal Med, New Taipei, Taiwan
机构:
Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Miaoli County, Taiwan
Natl Hlth Res Inst, Zhunan Township, TaiwanFu Jen Catholic Univ, Cardinal Tien Hosp, Dept Internal Med, New Taipei, Taiwan