Increase in Mitochondrial DNA Copy Number in Response to Ochratoxin A and Methanol-Induced Mitochondrial DNA Damage in Drosophila

被引：13

作者：

Mutlu, Ayse Gul ^{[1
]}

机构：

[1] Mehmet Akif Ersoy Univ, Dept Biol, Burdur, Turkey

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2012年 / 89卷 / 06期

关键词：

Methanol; Ochratoxin A; mtDNA copy number; mtDNA damage; OXIDATIVE STRESS; ADDUCT FORMATION; RAT; CELLS;

D O I：

10.1007/s00128-012-0826-1

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The current study examined the effects of ochratoxin A (OTA) and methanol on mitochondrial DNA (mtDNA). The results showed that methanol application caused approximately 29 % more damage than the control group, and that there were no significant differences among the other groups in terms of mtDNA damage. The application of 0.04 ng/mL OTA and 0.04 ng/mL OTA with methanol increased mtDNA copy number compared with the control and 0.005 ng/mL OTA with methanol groups. The copy number in the 0.04 ng/mL OTA group was approximately 16 % greater than in the control.

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收藏

页码：1129 / 1132

页数：4

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