PHARMACODYNAMICS Which trails are your drugs taking?

被引：12

作者：

Zhang, Rumin ^{[1
]}

机构：

[1] Merck Res Labs, Dept Pharmacol, Kenilworth, NJ 07065 USA

来源：

NATURE CHEMICAL BIOLOGY | 2015年 / 11卷 / 06期

关键词：

TARGET RESIDENCE TIME; BINDING-KINETICS; EFFICACY; SAFETY;

D O I：

10.1038/nchembio.1795

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Binding kinetics (BK) has an indispensable role in pharmacodynamics (PD). Incorporating slow BK into a mechanistic PD model is shown to have predictive value for in vitro cellular and in vivo animal antibacterial efficacy.

引用

页码：382 / 383

页数：2

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