The MINDVIEW project: First results

被引：25

作者：

Benlloch, Jose M. ^{[1
]}

Gonzalez, Antonio J. ^{[1
]}

Pani, Roberto ^{[2
]}

Preziosi, Enrico ^{[2
]}

Jackson, Carl ^{[3
]}

Murphy, John ^{[3
]}

Barbera, Julio ^{[4
]}

Correcher, Carlos ^{[4
]}

Aussenhofer, Sebastian ^{[5
]}

Gareis, Daniel ^{[5
]}

Visvikis, Dimitris ^{[6
]}

Bert, Julien ^{[6
]}

Langstrom, Bengt ^{[7
]}

Farde, Lars ^{[8
,9
,10
]}

Toth, Miklos ^{[8
,9
]}

Haggkvist, Jenny ^{[8
,9
]}

Caixeta, Fabio V. ^{[11
]}

Kullander, Klas ^{[11
]}

Somlai-Schweiger, Ian ^{[12
]}

Schwaiger, Markus ^{[12
]}

机构：

[1] Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain

[2] Sapienza Univ Rome, Dept Mol Med, Rome, Italy

[3] SensL Technol, Cork, Ireland

[4] Oncovision, Valencia, Spain

[5] NORAS MRI Prod GmbH, Hochberg, Germany

[6] Univ Bretagne Occidentale, INSERM, UMR1101, LaTIM, Brest, France

[7] BENCAR, Uppsala, Sweden

[8] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden

[9] Stockholm Cty Council, Stockholm, Sweden

[10] Karolinska Inst, PET Sci Ctr, AstraZeneca, Precis Med & Genom, Stockholm, Sweden

[11] Uppsala Univ, Dept Neurosci, Uppsala, Sweden

[12] Tech Univ Munich, Dept Nucl Med, Munich, Germany

来源：

EUROPEAN PSYCHIATRY | 2018年 / 50卷

关键词：

Schizophrenia; Positron Emission Tomography; Silicon photomultipliers and magnetic resonance; PET; GLUTAMATE; RECEPTORS; DOPAMINE; BRAIN; SCHIZOPHRENIA; TRANSPORTER; SENSITIVITY; RESPONSES; SLC10A4;

D O I：

10.1016/j.eurpsy.2018.01.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from C-11-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that C-11-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naive, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia. (c) 2018 Elsevier Masson SAS. All rights reserved.

引用

页码：21 / 27

页数：7

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