The MINDVIEW project: First results

被引:24
作者
Benlloch, Jose M. [1 ]
Gonzalez, Antonio J. [1 ]
Pani, Roberto [2 ]
Preziosi, Enrico [2 ]
Jackson, Carl [3 ]
Murphy, John [3 ]
Barbera, Julio [4 ]
Correcher, Carlos [4 ]
Aussenhofer, Sebastian [5 ]
Gareis, Daniel [5 ]
Visvikis, Dimitris [6 ]
Bert, Julien [6 ]
Langstrom, Bengt [7 ]
Farde, Lars [8 ,9 ,10 ]
Toth, Miklos [8 ,9 ]
Haggkvist, Jenny [8 ,9 ]
Caixeta, Fabio V. [11 ]
Kullander, Klas [11 ]
Somlai-Schweiger, Ian [12 ]
Schwaiger, Markus [12 ]
机构
[1] Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain
[2] Sapienza Univ Rome, Dept Mol Med, Rome, Italy
[3] SensL Technol, Cork, Ireland
[4] Oncovision, Valencia, Spain
[5] NORAS MRI Prod GmbH, Hochberg, Germany
[6] Univ Bretagne Occidentale, INSERM, UMR1101, LaTIM, Brest, France
[7] BENCAR, Uppsala, Sweden
[8] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden
[9] Stockholm Cty Council, Stockholm, Sweden
[10] Karolinska Inst, PET Sci Ctr, AstraZeneca, Precis Med & Genom, Stockholm, Sweden
[11] Uppsala Univ, Dept Neurosci, Uppsala, Sweden
[12] Tech Univ Munich, Dept Nucl Med, Munich, Germany
关键词
Schizophrenia; Positron Emission Tomography; Silicon photomultipliers and magnetic resonance; PET; GLUTAMATE; RECEPTORS; DOPAMINE; BRAIN; SCHIZOPHRENIA; TRANSPORTER; SENSITIVITY; RESPONSES; SLC10A4;
D O I
10.1016/j.eurpsy.2018.01.002
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from C-11-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that C-11-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naive, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia. (c) 2018 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:21 / 27
页数:7
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