Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model

被引：24

作者：

Kainulainen, Markus H. ^{[1
]}

Spengler, Jessica R. ^{[1
]}

Welch, Stephen R. ^{[1
]}

Coleman-McCray, JoAnn D. ^{[1
]}

Harmon, Jessica R. ^{[1
]}

Klena, John D. ^{[1
]}

Nichol, Stuart T. ^{[1
]}

Albarino, Cesar G. ^{[1
]}

Spiropoulou, Christina F. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 217卷 / 12期

关键词：

Lassa; vaccine; virus replicon particle; VRP; single-cycle replication; I INTERFERON INDUCTION; HUMAN DENDRITIC CELLS; VALLEY FEVER VIRUS; WEST-AFRICA; SIERRA-LEONE; DERMAL ELECTROPORATION; ARENAVIRUS INFECTION; NONHUMAN-PRIMATES; EASTERN PROVINCE; RIG-I;

D O I：

10.1093/infdis/jiy123

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lassa fever is a viral zoonosis that can be transmitted from person to person, especially in the hospital setting. The disease is endemic to several countries in West Africa and can be a major contributor to morbidity and mortality in affected areas. There are no approved vaccines to prevent Lassa virus infection. In this work, we present a vaccine candidate that combines the scalability and efficacy benefits of a live vaccine with the safety benefits of single-cycle replication. The system consists of Lassa virus replicon particles devoid of the virus essential glycoprotein gene, and a cell line that expresses the glycoprotein products, enabling efficient vaccine propagation. Guinea pigs vaccinated with these particles showed no clinical reaction to the inoculum and were protected against fever, weight loss, and lethality after infection with Lassa virus.

引用

页码：1957 / 1966

页数：10

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