Synthesis of a new 1,4-aminoalcohol and its use as catalyst in the enantioselective addition of organozinc to aldehydes

被引：17
|
作者：
Scarpi, Dina
Lo Galbo, Fabrizio
Guarna, Antonio
机构：
[1] Univ Florence, Dipartimento Chim Organ U Schiff Synth & Study Bi, HeteroBioLab, I-50019 Sesto Fiorentino, Italy
[2] Univ Florence, Lab Design Synth & Study Biol Act Heterocycles, I-50019 Sesto Fiorentino, Italy
来源：
TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 09期
关键词：
D O I：
10.1016/j.tetasy.2006.04.010
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis of a new enantiopure, conformationally constrained 1,4-aminoalcohol is reported, starting from commercially available reagents from the chiral pool. This 1,4-aminoalcohol was used as chiral ligand in the addition of Et-Zn-2 to aldehydes (best ee 98%) and in the synthesis of chiral propargylic alcohols (best ee 70%) by alkynylzinc species. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1409 / 1414
页数：6
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