Combined effect of PLGA and curcumin on wound healing activity

被引：220

作者：

Chereddy, Kiran Kumar ^{[1
]}

Coco, Regis ^{[1
]}

Memvanga, Patrick B. ^{[1
]}

Ucakar, Bernard ^{[1
]}

des Rieux, Anne ^{[1
]}

Vandermeulen, Gaelle ^{[1
]}

Preat, Veronique ^{[1
]}

机构：

[1] Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, Belgium

来源：

JOURNAL OF CONTROLLED RELEASE | 2013年 / 171卷 / 02期

关键词：

Skin wound healing; Poly (lactic-co-glycolic acid); Curcumin; Nanoparticles; Drug delivery; OXYGEN; NANOPARTICLES; LACTATE; RATS;

D O I：

10.1016/j.jconrel.2013.07.015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Wound healing is a complex process involving many interdependent and overlapping sequences of physiological actions. The application of exogenous lactate released from poly (lactic-co-glycolic acid) (PLGA) polymer accelerated angiogenesis and wound healing processes. Curcumin is a well-known topical wound healing agent for both normal and diabetic-impaired wounds. Hence, we hypothesized that the PLGA nanoparticles encapsulating curcumin could much potentially accelerate the wound healing. In a full thickness excisional wound healing mouse model, PLGA-curcumin nanoparticles showed a twofold higher wound healing activity compared to that of PLGA or curcumin. Histology and RT-PCR studies confirmed that PLGA-curcumin nanoparticles exhibited higher re-epithelialization, granulation tissue formation and anti-inflammatory potential. PLGA nanoparticles offered various benefits for the encapsulated curcumin like protection from light degradation, enhanced water solubility and showed a sustained release of curcumin over a period of 8 days. In conclusion, we demonstrated the additive effect of lactic acid from PLGA and encapsulated curcumin for the active healing of wounds. (C) 2013 Elsevier B. V. All rights reserved.

引用

页码：208 / 215

页数：8

共 26 条

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