Combined effect of PLGA and curcumin on wound healing activity

被引：220

作者：

Chereddy, Kiran Kumar ^{[1
]}

Coco, Regis ^{[1
]}

Memvanga, Patrick B. ^{[1
]}

Ucakar, Bernard ^{[1
]}

des Rieux, Anne ^{[1
]}

Vandermeulen, Gaelle ^{[1
]}

Preat, Veronique ^{[1
]}

机构：

[1] Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, Belgium

来源：

JOURNAL OF CONTROLLED RELEASE | 2013年 / 171卷 / 02期

关键词：

Skin wound healing; Poly (lactic-co-glycolic acid); Curcumin; Nanoparticles; Drug delivery; OXYGEN; NANOPARTICLES; LACTATE; RATS;

D O I：

10.1016/j.jconrel.2013.07.015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Wound healing is a complex process involving many interdependent and overlapping sequences of physiological actions. The application of exogenous lactate released from poly (lactic-co-glycolic acid) (PLGA) polymer accelerated angiogenesis and wound healing processes. Curcumin is a well-known topical wound healing agent for both normal and diabetic-impaired wounds. Hence, we hypothesized that the PLGA nanoparticles encapsulating curcumin could much potentially accelerate the wound healing. In a full thickness excisional wound healing mouse model, PLGA-curcumin nanoparticles showed a twofold higher wound healing activity compared to that of PLGA or curcumin. Histology and RT-PCR studies confirmed that PLGA-curcumin nanoparticles exhibited higher re-epithelialization, granulation tissue formation and anti-inflammatory potential. PLGA nanoparticles offered various benefits for the encapsulated curcumin like protection from light degradation, enhanced water solubility and showed a sustained release of curcumin over a period of 8 days. In conclusion, we demonstrated the additive effect of lactic acid from PLGA and encapsulated curcumin for the active healing of wounds. (C) 2013 Elsevier B. V. All rights reserved.

引用

页码：208 / 215

页数：8

共 26 条

[1] Synthesis and characterization of PLGA nanoparticles [J].

Astete, Carlos E. ;

Sabliov, Cristina M. .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2006, 17 (03) :247-289

[2] MEASUREMENT OF CUTANEOUS INFLAMMATION - ESTIMATION OF NEUTROPHIL CONTENT WITH AN ENZYME MARKER [J].

BRADLEY, PP ;

PRIEBAT, DA ;

CHRISTENSEN, RD ;

ROTHSTEIN, G .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1982, 78 (03) :206-209

[3] Novel insights into wound healing sequence of events [J].

Braiman-Wiksman, Liora ;

Solomonik, Inessa ;

Spira, Ram ;

Tennenbaum, Tamar .

TOXICOLOGIC PATHOLOGY, 2007, 35 (06) :767-779

[4] PLGA-based nanoparticles: An overview of biomedical applications [J].

Danhier, Fabienne ;

Ansorena, Eduardo ;

Silva, Joana M. ;

Coco, Regis ;

Le Breton, Aude ;

Preat, Veronique .

JOURNAL OF CONTROLLED RELEASE, 2012, 161 (02) :505-522

[5] Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings [J].

Fonder, Margaret A. ;

Lazarus, Gerald S. ;

Cowan, David A. ;

Aronson-Cook, Barbara ;

Kohli, Angela R. ;

Mamelak, Adam J. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2008, 58 (02) :185-206

[6] The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-A review [J].

Fredenberg, Susanne ;

Wahlgren, Marie ;

Reslow, Mats ;

Axelsson, Anders .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 415 (1-2) :34-52

[7] Analysis of myeloperoxidase activity in wound fluids as a marker of infection [J].

Hasmann, A. ;

Wehrschuetz-Sigl, E. ;

Marold, A. ;

Wiesbauer, H. ;

Schoeftner, R. ;

Gewessler, U. ;

Kandelbauer, A. ;

Schiffer, D. ;

Schneider, K. P. ;

Binder, B. ;

Schintler, M. ;

Guebitz, G. M. .

ANNALS OF CLINICAL BIOCHEMISTRY, 2013, 50 (03) :245-254

[8] REGULATION OF CUTANEOUS WOUND-HEALING BY GROWTH-FACTORS AND THE MICROENVIRONMENT [J].

KNIGHTON, DR ;

FIEGEL, VD .

INVESTIGATIVE RADIOLOGY, 1991, 26 (06) :604-611

[9] The Nuclear Factor NF-κB Pathway in Inflammation [J].

Lawrence, Toby .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2009, 1 (06) :a001651

[10]

Menon VP, 2007, ADV EXP MED BIOL, V595, P105

← 1 2 3 →