THE EFFECT OF NOVEL COMPOUND MCC950 ON THE NLRP3 INFLAMMASOME IN THE RA JOINT

被引:2
作者
McGarry, T. [1 ]
Robertson, A. A. [2 ]
Orr, C. [1 ]
Coll, R. C. [3 ]
Cooper, M. A. [2 ]
O'Neill, L. A. [3 ]
Veale, D. J. [1 ]
Fearon, U. [1 ]
机构
[1] Univ Coll Dublin, Dublin Acad Med Ctr, Ctr Arthrit & Rheumat Dis, Dublin, Ireland
[2] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[3] Trinity Biomed Sci Inst, Sch Biochem & Immunol, Dublin, Ireland
关键词
D O I
10.1136/annrheumdis-2015-eular.3985
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
THU0027
引用
收藏
页码:202 / 202
页数:1
相关论文
共 50 条
[41]   Adenine model of chronic renal failure in rats to determine whether MCC950, an NLRP3 inflammasome inhibitor, is a renopreventive [J].
Sabra, Mahmoud S. ;
Hemida, Fahmy K. ;
Allam, Essmat A. H. .
BMC NEPHROLOGY, 2023, 24 (01)
[42]   Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice [J].
Fan, Yunxia ;
Du, Liwu ;
Fu, Qun ;
Zhou, Zhiqiang ;
Zhang, Jingyu ;
Li, Guomin ;
Wu, Jing .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2018, 12
[43]   Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice [J].
Fu, Qun ;
Li, Jing ;
Qiu, Lili ;
Ruan, Jiaping ;
Mao, Mingjie ;
Li, Shuming ;
Mao, Qinghong .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 82
[44]   NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity [J].
Marin-Aguilar, Fabiola ;
Castejon-Vega, Beatriz ;
Alcocer-Gomez, Elisabet ;
Lendines-Cordero, Debora ;
Cooper, Matthew A. ;
de la Cruz, Patricia ;
Andujar-Pulido, Eloisa ;
Perez-Alegre, Monica ;
Muntane, Jordi ;
Perez-Pulido, Antonio J. ;
Ryffel, Bernhard ;
Robertson, Avril A. B. ;
Ruiz-Cabello, Jesus ;
Bullon, Pedro ;
Cordero, Mario D. .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2020, 75 (08) :1457-1464
[45]   MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice [J].
Agampodi Promoda Perera ;
Ruchira Fernando ;
Tanvi Shinde ;
Rohit Gundamaraju ;
Benjamin Southam ;
Sukhwinder Singh Sohal ;
Avril A. B. Robertson ;
Kate Schroder ;
Dale Kunde ;
Rajaraman Eri .
Scientific Reports, 8
[46]   NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitis [J].
Shen, Yanghui ;
Yang, Huobao ;
Wu, Dansen ;
Yang, Hangmei ;
Hong, Donghuang .
ACTA CIRURGICA BRASILEIRA, 2022, 37 (07)
[47]   NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia [J].
Ward, Rebecca ;
Li, Weiguo ;
Abdul, Yasir ;
Jackson, LaDonya ;
Dong, Guangkuo ;
Jamil, Sarah ;
Filosa, Jessica ;
Fagan, Susan C. ;
Ergul, Adviye .
PHARMACOLOGICAL RESEARCH, 2019, 142 :237-250
[48]   NLRP3 Inflammasome Inhibition With MCC950 Improves Diabetes-Mediated Cognitive Impairment and Vasoneuronal Remodeling After Ischemia [J].
Ward, Rebecca ;
Li Weiguo ;
Abdul, Yasir ;
Jackson, LaDonya ;
Dong Guangkuo ;
Jamil, Sarah ;
Filosa, Jessica ;
Fagan, Susan C. ;
Ergul, Adviye .
STROKE, 2019, 50
[49]   The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence [J].
Shi, Ying ;
Zhao, Lili ;
Wang, Jing ;
Liu, Shan ;
Zhang, Yifei ;
Qin, Qin .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2022, 937
[50]   MCC950, a NLRP3 inhibitor, ameliorates lipopolysaccharide-induced lung inflammation in mice [J].
Wang, Lu ;
Lei, Wu ;
Zhang, Shuijuan ;
Yao, Li .
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 30