Tandem O-H Insertion/[3,3]-Sigmatropic Rearrangement of Rhodium Carbenoids with 2-Furfuryl Alcohols: A Strategy To Access Polysubstituted Furans

被引：9
|
作者：
Mi, Pengbing [1 ,2 ]
Wang, Hannan [1 ,2 ]
Zhao, Rui [3 ]
Song, Jinna [2 ]
机构：
[1] Jilin Univ, Coll Life Sci, Changchun 130024, Jilin, Peoples R China
[2] Northeast Normal Univ, Dept Chem, Changchun 130024, Jilin, Peoples R China
[3] Jilin Univ, Dept Urol, China Japan Union Hosp, Changchun 130024, Jilin, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 06期
关键词：
Rhodium; Carbenoids; Domino reactions; Alcohols; Sigmatropic rearrangement; ONE-POT SYNTHESIS; CATALYZED SYNTHESIS; TERMINAL ALKYNES; STEREOSELECTIVE-SYNTHESIS; DIVERGENT SYNTHESIS; N-SULFONYL-1,2,3-TRIAZOLES; 1-SULFONYL-1,2,3-TRIAZOLES; TRANSANNULATION; CYCLOADDITION; BONDS;
D O I：
10.1002/ejoc.201701217
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Polysubstituted furans are versatile building blocks in organic synthesis and are widely spread in a variety of natural products, pharmaceuticals, and functional materials. Herein, we report a convenient, facile, and economic approach for the synthesis of polysubstituted furans through a tandem O-H insertion/[3,3]-sigmatropic rearrangement of rhodium carbenoids with easily available furfuryl alcohols. This protocol is characterized by its operational simplicity, high efficiency with excellent yields, broad substrate scope, and great functional-group tolerance.
引用
收藏
页码：759 / 762
页数：4
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