Traumatic Brain Injury and Suicidal Behavior: A Review

被引：17

作者：

Wadhawan, Abhishek ^{[1
,2
]}

Stiller, John W. ^{[1
,3
,4
]}

Potocki, Eileen ^{[5
]}

Okusaga, Olaoluwa ^{[1
,6
,7
]}

Dagdag, Aline ^{[1
,8
]}

Lowry, Christopher A. ^{[9
,10
,11
,12
,13
]}

Benros, Michael E. ^{[14
]}

Postolache, Teodor T. ^{[1
,13
,15
]}

机构：

[1] Univ Maryland, Dept Psychiat, Mood & Anxiety Program, Sch Med, 685 W Baltimore St,MSTF Bldg,Suite 930, Baltimore, MD 21201 USA

[2] St Elizabeth Hosp, Psychiat Residency Training Program, Washington, DC USA

[3] St Elizabeth Hosp, Neurol Consultat Serv, Washington, DC USA

[4] Maryland State Athlet Commiss, Baltimore, MD USA

[5] VA Maryland Healthcare Syst, Baltimore VA Med Ctr, Baltimore, MD USA

[6] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA

[7] Michael E DeBakey VA Med Ctr, Houston, TX USA

[8] Univ Maryland, Med Ctr, Dept Psychiat, Baltimore, MD 21201 USA

[9] Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA

[10] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA

[11] Univ Colorado, Dept Phys Med & Rehabil, Anschutz Med Campus, Aurora, CO USA

[12] Univ Colorado, Ctr Neurosci, Anschutz Med Campus, Aurora, CO USA

[13] Mil & Vet Microbiome Consortium Res & Educ MVM Co, Vet Integrated Serv Network VISN 19, Rocky Mt Mental Illness Res Educ & Clin Ctr MIREC, Aurora, CO USA

[14] Copenhagen Univ Hosp, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark

[15] VA Capitol Hlth Care Network, VISN 5, MIRECC, Baltimore, MD USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2019年 / 68卷 / 04期

关键词：

Chronic traumatic encephalopathy; death by suicide; inflammation; neuroinflammation; suicidal behavior; traumatic brain injury; RANDOMIZED CONTROLLED-TRIAL; INTERPERSONAL-PSYCHOLOGICAL THEORY; DEFENSIVE RAGE BEHAVIOR; DEPRESSIVE-LIKE BEHAVIOR; PERIAQUEDUCTAL GRAY PAG; D-ASPARTATE ANTAGONIST; NMDA RECEPTOR COMPLEX; ALZHEIMERS-DISEASE; RISK-FACTORS; HEAD-INJURY;

D O I：

10.3233/JAD-181055

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Given the increasing rate of death by suicide in the United States, it is imperative to examine specific risk factors and to identify possible etiologies of suicidal behavior in at-risk clinical subpopulations. There is accumulating evidence to support an elevated risk of death by suicide in individuals with a history of traumatic brain injury (TBI). In this review article, after defining terms used in suicidology, we discuss the associations of TBI with death by suicide, suicide attempt, and suicidal ideation. A model for repetitive TBIs, leading to chronic traumatic encephalopathy, is also discussed as a neuroinflammatory process, with discussion about its possible link with suicide. The review concludes with an overview of interventions to prevent suicidal behavior.

引用

页码：1339 / 1370

页数：32

共 402 条

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