Tetrapyrrolic glycosylated macrocycles for an application in PDT

被引：39
作者：
Momenteau, M
Maillard, P
De Bélinay, MA
Carrez, D
Croisy, A
机构：
[1] Ctr Univ Orsay, INSERM,U350, Inst Curie Sect Rech, Lab Raymond Latarjet, F-91405 Orsay, France
[2] Ctr Univ Orsay, CNRS,UMR 176, Inst Curie Sect Rech, Lab Raymond Latarjet, F-91405 Orsay, France
来源：
JOURNAL OF BIOMEDICAL OPTICS | 1999年 / 4卷 / 03期
关键词：
glycoconjugated porphyrins; benzochlorin; azaporphyrins; photocytotoxicity; synthesis;
D O I：
10.1117/1.429932
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis and characterization of amphiphilic glycoconjugated porphyrins, benzochlorin, and azaporphyrins were reported. Among these molecules, several were found to be efficient photosensitizers in an in vitro assay using the human tumoral cell line HT29. Moreover, glycosylated benzochlorin and azaporphyrins, whose absorption bands in the red region of the visible spectrum are substantially increased as compared to porphyrins, display a good photocytotoxicity on tumor cells after irradiation with wavelength above 590 nm. (C) 1999 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(99)00703-0].
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收藏
页码：298 / 318
页数：21
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