Haemophilus influenzae type b combination vaccines and atopic disorders: A prospective cohort study

被引:10
作者
Wang, I-Jen [1 ,2 ]
Huang, Li-Min [3 ]
Guo, Yueliang Leon [4 ]
Hsieh, Wu-Shiun [3 ]
Lin, Tien-Jen [5 ]
Chen, Pau-Chung [6 ]
机构
[1] Taipei Hosp, Dept Hlth, Dept Pediat, Taipei, Taiwan
[2] China Med Univ, Coll Publ Hlth, Taichung, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Pediat, Taipei, Taiwan
[4] Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, Taipei, Taiwan
[5] Taipei Med Univ, Wan Fang Hosp, Taipei, Taiwan
[6] Natl Taiwan Univ, Inst Occupat Med & Ind Hyg, Coll Publ Hlth, Taipei 10055, Taiwan
关键词
atopic dermatitis; Haemophilus influenzae type b; recurrent wheezing; vaccines; RISK-FACTORS; DERMATITIS; VACCINATION; CHILDREN; DIPHTHERIA; PERTUSSIS; TETANUS; LIFE; PREVALENCE; ALLERGY;
D O I
10.1016/j.jfma.2011.09.022
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Purpose: Epidemiologic evidence for an association between vaccinations and atopy development is inconsistent. We evaluated the influence of Haemophilus influenzae type b (Hib) combination vaccines in 6-month-old infants on the prevalence of atopic disorders in 18-month-old children. Methods: We used multistage, stratified systematic sampling to recruit 24,200 mother-newborn pairs from the Taiwan national birth registration in 2005. Vaccination status was ascertained through official vaccine cards, while risk factors for atopic disorders were gathered by questionnaires at 6 months of age. Information about development of atopic dermatitis (AD) and recurrent wheezing was collected at 18 months of age. The relationship between atopic disorders and Hib combination vaccines, diphtheria-pertussis-tetanus-Hib and oral poliomyelitis vaccines (DPT-Hib&OPV) and DPT-Hib-inactivated poliomyelitis vaccines (DPT-Hib-IPV), were estimated by multiple logistic regression. Results: A total of 19,968 children completed the follow-up and participated in the study. AD was noted in 1584 (7.9%) infants while recurrent wheezing was found in 1220 (6.1%) infants. The adjusted odds ratios (ORs) (95% CI) for the development of AD in the DPT-Hib&OPV and DPT-Hib-IPV vaccination groups were given as 1.38 (1.15-1.65) and 1.49 (1.29-1.72), compared to those without Hib vaccination (DTP&OPV vaccination). However, the association between DPT-Hib&OPV and DPT-Hib-IPV vaccinations and recurrent wheezing failed to reach statistical significance. Conclusion: There is a potential risk for AD after receiving Rib combination vaccines. Hib vaccination is important to the public health, and therefore the observation requires further investigations. Copyright (C) 2012, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
引用
收藏
页码:711 / 718
页数:8
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