The XIIIth Banff Conference on Allograft Pathology: The Banff 2015 Heart Meeting Report: Improving Antibody-Mediated Rejection Diagnostics: Strengths, Unmet Needs, and Future Directions

被引：48

作者：

Bruneval, P. ^{[1
,2
]}

Angelini, A. ^{[3
]}

Miller, D. ^{[4
]}

Potena, L. ^{[5
]}

Loupy, A. ^{[6
]}

Zeevi, A. ^{[7
]}

Reed, E. F. ^{[8
]}

Dragun, D. ^{[9
,10
]}

Reinsmoen, N. ^{[11
]}

Smith, R. N. ^{[12
]}

West, L. ^{[13
,14
]}

Tebutt, S. ^{[15
]}

Thum, T. ^{[16
]}

Haas, M. ^{[17
]}

Mengel, M. ^{[18
]}

Revelo, P. ^{[4
]}

Fedrigo, M. ^{[3
]}

Huyen, J. P. Duong Van ^{[6
]}

Berry, G. J. ^{[19
]}

机构：

[1] Univ Paris Descartes Med, Paris Translat Res Ctr Organ Transplantat, Paris, France

[2] Univ Paris Descartes Med, Hop Europeen Georges Pompidou, Dept Pathol, Paris, France

[3] Univ Padua, Sch Med, Dept Cardiac Thorac & Vasc Sci, Padua, Italy

[4] Univ Utah, Intermt Med Ctr, Salt Lake City, UT USA

[5] Univ Bologna, Acad Hosp S, Heart & Lung Transplant Program, Orsola Malpighi, Italy

[6] Univ Paris 05, Necker Hosp, Paris Translat Res Ctr Organ Transplantat, INSERM,U970, Paris, France

[7] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[8] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA USA

[9] Charite, Berlin Inst Hlth, Berlin, Germany

[10] Charite, Dept Nephrol & Crit Care Med, Berlin, Germany

[11] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[12] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[13] Alberta Transplant Inst, Edmonton, AB, Canada

[14] Univ Alberta, Edmonton, AB, Canada

[15] St Pauls Hosp, Ctr Heart Lung Innovat, Vancouver, BC, Canada

[16] Hannover Med Sch, IFB, Mol & Translat Therapeut Strategies, Hannover, Germany

[17] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

[18] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada

[19] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2017年 / 17卷 / 01期

关键词：

clinical research; practice; heart transplantation; cardiology; rejection; rejection: antibody-mediated (ABMR); rejection: subclinical; translational research; science; NON-HLA-ANTIBODIES; ANGIOTENSIN TYPE-1 RECEPTOR; DONOR-SPECIFIC ANTIBODIES; S6; RIBOSOMAL-PROTEIN; CARDIAC ALLOGRAFT; TRANSPLANT RECIPIENTS; ENDOMYOCARDIAL BIOPSIES; KIDNEY-TRANSPLANTATION; WORKING FORMULATION; INCREASED RISK;

D O I：

10.1111/ajt.14112

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The 13th Banff Conference on Allograft Pathology was held in Vancouver, British Columbia, Canada from October 5 to 10, 2015. The cardiac session was devoted to current diagnostic issues in heart transplantation with a focus on antibody-mediated rejection (AMR) and small vessel arteriopathy. Specific topics included the strengths and limitations of the current rejection grading system, the central role of microvascular injury in AMR and approaches to semiquantitative assessment of histopathologic and immunophenotypic indicators, the role of AMR in the development of cardiac allograft vasculopathy, the important role of serologic antibody detection in the management of transplant recipients, and the potential application of new molecular approaches to the elucidation of the pathophysiology of AMR and potential for improving the current diagnostic system. Herein we summarize the key points from the presentations, the comprehensive, open and wide-ranging multidisciplinary discussion that was generated, and considerations for future endeavors. This article summarizes the Banff conference on heart transplantation with a focus on antibody-mediated rejection, strengths and limitations of the current rejection grading system, the important role of serologic antibody detection and the potential application of new molecular approaches to the elucidation of the pathophysiology of antibody-mediated rejection, and the potential for improving the current diagnostic system. See the companion report on page 28.

引用

页码：42 / 53

页数：12

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