Rapid Detection of the Antibiotic Sulfamethazine in Pig Body Fluids by Paper Spray Mass Spectrometry

被引：29
作者：
Suraritdechachai, Surased [1 ,2 ]
Charoenpakdee, Chayan [1 ,3 ]
Young, Iain [4 ]
Maher, Simon [5 ]
Vilaivan, Tirayut [1 ,3 ]
Praneenararat, Thanit [1 ,2 ]
机构：
[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Phayathai Rd, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Fac Sci, Chem Approaches Food Applicat Res Grp, Phayathai Rd, Bangkok 10330, Thailand
[3] Chulalongkorn Univ, Fac Sci, Dept Chem, Organ Synth Res Unit, Phayathai Rd, Bangkok 10330, Thailand
[4] Univ Liverpool, Inst Integrat Biol, Crown St, Liverpool L69 7ZB, Merseyside, England
[5] Univ Liverpool, Dept Elect Engn & Elect, Brownlow Hill, Liverpool L69 3GJ, Merseyside, England
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2019年 / 67卷 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
paper spray; mass spectrometry; sulfamethazine; extraction; ambient ionization; SOLID-PHASE EXTRACTION; PERFORMANCE LIQUID-CHROMATOGRAPHY; SULFONAMIDE RESIDUES; QUANTITATIVE-ANALYSIS; VETERINARY DRUGS; ANIMAL-TISSUES; MICROEXTRACTION; BLOOD; SAMPLES; MILK;
D O I：
10.1021/acs.jafc.9b00500
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
We report herein a practical method for nonlethal detection of the antibiotic sulfamethazine in pig body fluids via the combination of simple extraction and paper spray mass spectrometry (PS-MS). This method requires minimal sample preparation while still providing high sensitivities and accuracies in complex matrices including pig whole blood (LOD = 7.9 mu g/L; recovery = 95.4-103.7%), pig serum (LOD = 11.5 mu g/L; recovery = 103.2-106.2%), and synthetic urine (LOD = 11.2 mu g/L; recovery = 99.1-103.2%). Given a known correlation between the level of sulfamethazine in body fluids and edible tissues, this method shows great promise as a practical and nonlethal solution for rapid testing of the drug, which can substantially aid managerial decision in the livestock industry.
引用
收藏
页码：3055 / 3061
页数：7
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