A neuronal nitric oxide synthase inhibitor 7-nitroindazole reduces the 5-HT1A receptor agonist 8-OH-DPAT-elicited hyperphagia in rats

被引：14
作者：
Sugimoto, Y [1 ]
Yamada, J [1 ]
Yoshikawa, T [1 ]
机构：
[1] Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Kobe, Hyogo 6588558, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 376卷 / 1-2期
关键词：
8-OH-DPAT (8-hydroxy-2-di-n-(propylamino)tetralin); nitric oxide (NO); 7-nitroindazole; 5-HT1A receptor; 5-HT; (5-hydroxytryptamine; serotonin); hypothalamus;
D O I：
10.1016/S0014-2999(99)00378-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of the neuronal nitric oxide (NO) synthase inhibitor 7-nitroindazole on 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT)-induced hyperphagia, which is mediated by the 5-HT1A autoreceptor, were investigated in rats. 7-Nitroindazole suppressed 8-OH-DPAT-elicited increases in food intake. The inhibitory effects of 7-nitroindazole on 8-OH-DPAT-induced feeding were prevented by the NO precursor L-arginine. Although 8-OH-DPAT decreases 5-hydroxytryptamine (5-HT) synthesis, 7-nitroindazole did not reverse the 8-OH-DPAT-elicited decrease in 5-HT synthesis. Therefore, these results indicate that NO formed in the brain is involved in 8-OH-DPAT-induced hyperphagia and that the hypophagic effects of 7-nitroindazole are not dependent on 5-HT synthesis. (C) 1999 Elsevier Science B.V. All rights reserved.
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页码：1 / 5
页数：5
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