Synthesis of o-(Dimethylamino)aryl Ketones, Acridones, Acridinim Salts, and 1H-Indazoles by the Reaction of Hydrazones and Arynes

被引：36

作者：

Dubrovskiy, Anton V. ^{[1
]}

Larock, Richard C. ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 24期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

ONE-POT SYNTHESIS; FACILE N-ARYLATION; 3-SUBSTITUTED INDAZOLES; ELECTRON-TRANSFER; DERIVATIVES; ALKALOIDS; AMINES; REDUCTION; CHEMISTRY; BENZYNE;

D O I：

10.1021/jo302378w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, efficient route to biologically and pharmaceutically important o-(dimethylamino)aryl ketones, acridones, acridinium salts, and 1H-indazoles has been developed starting from readily available hydrazones of aldehydes and o-(trimethylsilyl)aryl triflates. The reaction proceeds through arynes under mild conditions, tolerates a wide range of functional groups, and provides the final products in good to excellent yields.

引用

收藏

页码：11232 / 11256

页数：25

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