Migraine: a brain state

被引:54
作者
Charles, Andrew [1 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Headache Res & Treatment Program, Dept Neurol, Los Angeles, CA 90095 USA
关键词
adenosine; astrocytes; headache; resting states; sleep; HIGH-FREQUENCY OSCILLATIONS; GENOME-WIDE ASSOCIATION; PREMONITORY SYMPTOMS; NETWORK CONNECTIVITY; EVOKED POTENTIALS; ACTIVATION; SLEEP; PAIN; CONSCIOUSNESS; POSTDROME;
D O I
10.1097/WCO.0b013e32836085f4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose of review Migraine has traditionally been categorized as a pain disorder, focusing on headache as its central feature. This narrow view does not account for the complex array of premonitory and postrdromal symptoms that occur in the hours before and after headache. This review outlines evidence that supports a broader view of migraine as a pathological brain state. Recent findings Studies of the clinical features of a migraine attack, in combination with imaging and electrophysiological studies, provide evidence that migraine involves widespread changes in brain function and connectivity. These changes parallel those seen in other brain states such as sleep. Neurochemical mediators, including adenosine, and nonsynaptic signalling mechanisms involving astrocytes may play a role in the migraine state. Summary Consideration of a migraine attack as a brain state provides an expanded framework for understanding all of its symptoms, and the underlying alterations in the activity of multiple brain networks. Mechanisms driving the transition to the migraine state may represent novel targets for acute and preventive therapies.
引用
收藏
页码:235 / 239
页数:5
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