Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones

被引：85

作者：

Mueller, Andreas ^{[2
]}

Gooren, Louis ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Endocrinol, NL-1081 HV Amsterdam, Netherlands

[2] Erlangen Univ Hosp, Dept Obstet & Gynecol, D-91054 Erlangen, Germany

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2008年 / 159卷 / 03期

关键词：

D O I：

10.1530/EJE-08-0289

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: to assess the risk of development of hormone-related tumors in transsexuals receiving treatment with cross-sex hormones. Design: Description of cases of transsexuals who have developed a hormone-related malignancy observed in their own clinic or reported in the literature. Recommendations for early diagnosis and prevention are presented. Methods: Review of the literature in PubMed. Results: In male-to-female transsexuals receiving estrogen administration, lactotroph adenomas, breast cancer, and prostate cancer have been reported. In female-to-male transsexuals receiving treatment with testosterone, a single case of breast carcinoma and several cases of ovarian cancer have been reported. So far endometrial cancer has not been encountered though it remains a potential malignant development. Conclusions: There are so far only a few cases of hormone-related cancer in transsexuals. There may be an underreporting. The probability of a hormone-related turner increases with the duration of exposure to cross-sex hormones and the aging of the population of transsexuals.

引用

页码：197 / 202

页数：6

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