Physico-Chemical Characterization of the Inclusion Complexes Containing the Monoterpenes Camphor and 1,8-Cineol, Major Constituents of the Essential Oils of Croton conduplicatus, in β-Cyclodextrin

被引：3

作者：

Alves, C. S. C. ^{[1
]}

Oliveira, A. P. ^{[1
]}

Oliveira-Junior, R. G. ^{[1
]}

Santos, R. F. ^{[1
]}

Santos, A. D. C. ^{[1
]}

Tavares, G. F. ^{[1
]}

Almeida, J. R. G. S. ^{[1
]}

机构：

[1] Univ Fed Vale Sao Francisco, Nucleo Estudos & Pesquisas Plantas Med NEPLAME, BR-56304205 Petrolina, PE, Brazil

来源：

REVISTA VIRTUAL DE QUIMICA | 2019年 / 11卷 / 02期

关键词：

Euphorbiaceae; Croton conduplicatus; cyclodextrins; nuclear magnetic resonance;

D O I：

10.21577/1984-6835.20190030

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclodextrins (CDs) constitute a class of pharmaceutical excipients composed of D-glucopyranose units. Through the formation of inclusion complexes with CDs it is possible to administer nonpolar substances, such as monoterpenes, and evaluate their pharmacological activity. Considering the relevance of the discovery of new drugs, as well as the need to develop new pharmaceutical forms, this study aimed to develop inclusion complexes of monoterpenes contained in the essential oils of leaves and stem bark of Croton conduplicatus in beta-cyclodextrin. The complexes were prepared and characterized by nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The analysis allowed us to conclude that there was in fact the formation of the inclusion complexes of camphor and 1,8-cineole in beta-cyclodextrin, and the results were important to complement the studies being carried out in the area of pharmaceutical technology.

引用

页码：401 / 410

页数：10

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