Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities

被引：50

作者：

Ayeni, Emmanuel A. ^{[1
,2
]}

Aldossary, Ahmad M. ^{[3
]}

Ayejoto, Daniel A. ^{[4
]}

Gbadegesin, Lanre A. ^{[2
,5
]}

Alshehri, Abdullah A. ^{[3
]}

Alfassam, Haya A. ^{[6
]}

Afewerky, Henok K. ^{[7
,8
]}

Almughem, Fahad A. ^{[3
]}

Bello, Saidu M. ^{[9
]}

Tawfik, Essam A. ^{[3
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] King Abdulaziz City Sci & Technol KACST, Natl Ctr Biotechnol, Life Sci & Environm Res Inst, Riyadh 12354, Saudi Arabia

[4] Univ Ilorin, Dept Ind Chem, Ilorin 240003, Nigeria

[5] Chinese Acad Sci, Inst Mt Hazards & Environm, Chengdu 610041, Peoples R China

[6] King Abdulaziz City Sci & Technol KACST, Joint Ctr Excellence Program, KACST BWH Ctr Excellence Biomed, Riyadh 12354, Saudi Arabia

[7] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Neurobiol, Wuhan 430074, Peoples R China

[8] Asmara Coll Hlth Sci, Sch Allied Hlth Profess, POB 1220, Asmera, Eritrea

[9] Univ Szeged, Inst Pharmacognosy, H-6720 Szeged, Hungary

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2022年 / 19卷 / 19期

关键词：

neurodegenerative diseases; hormones; neurotransmitters; environment; climate; public health; TRAUMATIC BRAIN-INJURY; PARKINSONS-DISEASE; OXIDATIVE STRESS; NEUROLOGICAL DISORDERS; ALZHEIMERS-DISEASE; THYROID-HORMONE; MENTAL-HEALTH; CELL-DEATH; INFLAMMATION; DEPLETION;

D O I：

10.3390/ijerph191912495

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative diseases (NDDs) increases with age. Neuronal hormones and neurotransmitters are major determinant factors regulating brain structure and functions. The implications of environmental and climatic changes emerged recently as influence factors on numerous diseases. However, the complex interaction of neurotransmitters and neuronal hormones and their depletion under environmental and climatic influences on NDDs are not well established in the literature. In this review, we aim to explore the connection between the environmental and climatic factors to NDDs and to highlight the available and potential therapeutic interventions that could use to improve the quality of life and reduce susceptibility to NDDs.

引用

页数：24

共 236 条

[1] Improvement in inflammation is associated with the protective effect of Gly-Pro-Glu and cycloprolylglycine against Aβ-induced depletion of the hippocampal somatostatinergic system [J].