Microwave-assisted continuous flow synthesis on industrial scale

被引：109

作者：

Morschhaeuser, Roman ^{[1
]}

Krull, Matthias ^{[1
]}

Kayser, Christoph ^{[1
]}

Boberski, Cornelia ^{[2
]}

Bierbaum, Ralf ^{[1
]}

Pueschner, Peter A. ^{[3
]}

Glasnov, Toma N. ^{[4
,5
]}

Kappe, C. Oliver ^{[4
,5
]}

机构：

[1] Clariant Prod Deutschland GmbH, D-65926 Frankfurt, Germany

[2] Innoturn GmbH, D-65779 Kelkheim, Germany

[3] Puschner GmbH & Co KG, D-28790 Schwanewede, Germany

[4] Karl Franzens Univ Graz, Christian Doppler Lab Microwave Chem, A-80010 Graz, Austria

[5] Karl Franzens Univ Graz, Inst Chem, A-80010 Graz, Austria

来源：

GREEN PROCESSING AND SYNTHESIS | 2012年 / 1卷 / 03期

关键词：

continuous flow chemistry; high-temperature/high-pressure process windows; microwave chemistry; process intensification; PROCESS WINDOWS; BATCH; CHEMISTRY; REACTOR; SULTAMS; PLANT;

D O I：

10.1515/gps-2012-0032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A continuous flow microwave system based on a transmission line short-circuited waveguide reactor concept is described. The continuous flow reactor is capable of operating in a genuine high-temperature/high-pressure process window (310 degrees C/60 bar), applying a microwave transparent and chemical resistant cylindrical gamma-Al2O3 tube as reaction zone. The system can be operated in an extremely energy efficient manner, utilizing 0.6-6 kW microwave power (2.45 GHz). The application of the reactor for processing four chemical transformations in a high-temperature/high-pressure regime with a throughout of 3.5-6.0 l/h is demonstrated.

引用

页码：281 / 290

页数：10

共 50 条

[1] Microwave-assisted continuous flow synthesis of propofol
Sagandira, Cloudius R.
Len, Christophe
SUSTAINABLE CHEMISTRY AND PHARMACY, 2024, 42
[2] Microwave-assisted continuous flow reactions
Porter, Keith A.
Vanier, Grace S.
Barnhardt, E. Keller
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
[3] A microreactor for microwave-assisted capillary (continuous flow) organic synthesis
Comer, E
Organ, MG
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (22) : 8160 - 8167
[4] Microwave-assisted synthesis under continuous-flow conditions
Glasnov, Toma N.
Kappe, C. Oliver
MACROMOLECULAR RAPID COMMUNICATIONS, 2007, 28 (04) : 395 - 410
[5] A microreactor for microwave-assisted capillary (continuous flow) organic synthesis
Comer, Eamon
Organ, Michael G.
Journal of the American Chemical Society, 2005, 127 (22): : 8160 - 8167
[6] Microwave-Assisted Industrial Scale Cannabis Extraction
Radoiu, Marilena
Kaur, Harmandeep
Bakowska-Barczak, Anna
Splinter, Steven
TECHNOLOGIES, 2020, 8 (03)
[7] Multicomponent reactions to form heterocycles by microwave-assisted continuous flow organic synthesis
Bremner, W. Stacy
Organ, Michael G.
JOURNAL OF COMBINATORIAL CHEMISTRY, 2007, 9 (01): : 14 - 16
[8] A continuous flow microwave-assisted fischer indole synthesis of 7-Ethyltryptophol
Xu, Jianguo
Yu, Jiangang
Jin, Yi
Li, Jie
Yu, Zhiqun
Lv, Yanwen
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2017, 121 : 144 - 148
[9] Microwave-Assisted Continuous Flow for the Selective Oligomerization of Glycerol
Nguyen, Remi
Galy, Nicolas
Alasmary, Fatmah Ali
Len, Christophe
CATALYSTS, 2021, 11 (02) : 1 - 7
[10] Microwave-assisted Continuous Flow Process of Biodiesel Production
Zhu, Huacheng
Hong, Tao
Yang, Fan
2018 ASIA-PACIFIC MICROWAVE CONFERENCE PROCEEDINGS (APMC), 2018, : 276 - 278

← 1 2 3 4 5 →