Microwave-assisted continuous flow synthesis on industrial scale

被引：111
作者：
Morschhaeuser, Roman [1 ]
Krull, Matthias [1 ]
Kayser, Christoph [1 ]
Boberski, Cornelia [2 ]
Bierbaum, Ralf [1 ]
Pueschner, Peter A. [3 ]
Glasnov, Toma N. [4 ,5 ]
Kappe, C. Oliver [4 ,5 ]
机构：
[1] Clariant Prod Deutschland GmbH, D-65926 Frankfurt, Germany
[2] Innoturn GmbH, D-65779 Kelkheim, Germany
[3] Puschner GmbH & Co KG, D-28790 Schwanewede, Germany
[4] Karl Franzens Univ Graz, Christian Doppler Lab Microwave Chem, A-80010 Graz, Austria
[5] Karl Franzens Univ Graz, Inst Chem, A-80010 Graz, Austria
来源：
GREEN PROCESSING AND SYNTHESIS | 2012年 / 1卷 / 03期
关键词：
continuous flow chemistry; high-temperature/high-pressure process windows; microwave chemistry; process intensification; PROCESS WINDOWS; BATCH; CHEMISTRY; REACTOR; SULTAMS; PLANT;
D O I：
10.1515/gps-2012-0032
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A continuous flow microwave system based on a transmission line short-circuited waveguide reactor concept is described. The continuous flow reactor is capable of operating in a genuine high-temperature/high-pressure process window (310 degrees C/60 bar), applying a microwave transparent and chemical resistant cylindrical gamma-Al2O3 tube as reaction zone. The system can be operated in an extremely energy efficient manner, utilizing 0.6-6 kW microwave power (2.45 GHz). The application of the reactor for processing four chemical transformations in a high-temperature/high-pressure regime with a throughout of 3.5-6.0 l/h is demonstrated.
引用
收藏
页码：281 / 290
页数：10
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