Novel synthesis of 7-β-D-ribofuranosyl-7H-1,2,4-triazolo[3,4-i]purines with use of NBS

被引：9

作者：

Chen, HJ ^{[1
]}

Shang, ZH ^{[1
]}

Chang, JB ^{[1
]}

机构：

[1] Tianjin Univ, Coll Pharmaceut & Biotechnol, Tianjin 300072, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 04期

基金：

中国国家自然科学基金;

关键词：

NBS; 7H-1,2,4-triazolo[3,4-i]purine; xanthine dehydrogenase (XDH); xanthine oxidase (XO);

D O I：

10.1080/00397910500383501

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

7-ss-D-Ribofuranosyl-7 H -1,2,4-triazolo[3,4-i]purine derivatives were synthesized through the NBS-promoted oxidative cyclization of the corresponding hydrazones.

引用

页码：445 / 450

页数：6

共 15 条

[1]

AHMAD SS, 2002, TETRAHEDRON, V58, P8559

[2]

Anil K. S., 2003, EUR J MED CHEM, V38, P533

[3] Allopurinol, an inhibitor of xanthine oxidase, reduces uric acid levels and modifies the signs associated with copper deficiency in rats fed fructose [J].

Fields, M ;

Lewis, CG ;

Lure, MD .

FREE RADICAL BIOLOGY AND MEDICINE, 1996, 20 (04) :595-600

[4]

GIULIANA B, 1999, J HETEROCYCLIC CHEM, V36, P1195

[5] A MILD AND REGIOSPECIFIC SYNTHESIS OF 3-AMINO SUBSTITUTED TRIAZOLO-[4,3-C]-PYRIMIDINES BY CYCLIZATION OF 4-HYDRAZINOPYRIMIDINES WITH IMINIUM CHLORIDES AND WITH N-ARYL PHOSGENIMINES [J].

GUILLOT, N ;

VIEHE, HG ;

TINANT, B ;

DECLERCQ, JP .

TETRAHEDRON, 1990, 46 (11) :3897-3908

[6] Allopurinol induces renal toxicity by impairing pyrimidine metabolism in mice [J].

Horiuchi, H ;

Ota, M ;

Nishimura, S ;

Kaneko, H ;

Kasahara, Y ;

Ohta, T ;

Komoriya, K .

LIFE SCIENCES, 2000, 66 (21) :2051-2070

[7]

IRENA M, 2001, SYNTHETIC COMMUN, V31, P1511

[8]

JUNICHI S, 1992, TETRAHEDRON LETT, V33, P3151

[9]

MANY A, 1995, J SOC GYNECOL INVEST, V2, P286

[10]

MANY A, 1996, INT J GYNECOL OBSTET, V54, P214

← 1 2 →