The dynamical-quantization approach to open quantum systems does consist in quantizing the Brownian motion starting directly from its stochastic dynamics under the framework of both Langevin and Fokker-Planck equations, without alluding to any model Hamiltonian. On the ground of this non-Hamiltonian quantization method, we can derive a non-Markovian Caldeira-Leggett quantum master equation as well as a non-Markovian quantum Smoluchowski equation. The former is solved for the case of a quantum Brownian particle in a gravitational field whilst the latter for a harmonic oscillator. In both physical situations, we come up with the existence of a non-equilibrium thermal quantum force and investigate its classical limit at high temperatures as well as its quantum limit at zero temperature. Further, as a physical application of our quantum Smoluchowski equation, we take up the tunneling phenomenon of a non-inertial quantum Brownian particle over a potential barrier. Lastly, we wish to point out, corroborating conclusions reached in our previous paper [A. O. Bolivar, Ann. Phys. 326 (2011) 1354], that the theoretical predictions in the present article uphold the view that our non-Hamiltonian quantum mechanics is able to capture novel features inherent in quantum Brownian motion, thereby overcoming shortcomings underlying the Caldeira-Leggett Hamiltonian model. (C) 2011 Elsevier Inc. All rights reserved.