Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

被引：9

作者：

Chronopoulos, A. ^{[2
]}

Pleyer, U. ^{[1
]}

Mockenhaupt, M. ^{[3
]}

机构：

[1] Univ Augenklin, D-13353 Berlin, Germany

[2] Univ Med, Klin Augenheilkunde, Berlin, Germany

[3] Univ Hautklinik Freiburg, Dokumentationszentrum Schwerer Hautreaktionen dZh, Freiburg, Germany

来源：

KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE | 2012年 / 229卷 / 05期

关键词：

cornea; conjunctiva; pathology; Stevens-Johnson syndrome; toxic epidermal necrolysis; ocular manifestation; ERYTHEMA MULTIFORME; INTRAVENOUS IMMUNOGLOBULIN; SURFACE DISEASE; MANIFESTATIONS; TRANSPLANTATION; MANAGEMENT; MORTALITY; PATTERNS; EUROSCAR; THERAPY;

D O I：

10.1055/s-0031-1299530

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe reactions of skin and mucous membranes. They are considered as a single disease entity with differing severities and are mainly induced by drugs, less frequently by infections. In 50 % of the patients ocular complications occur, which can lead to blindness in the absence of immediate ophthalmological treatment. The acute pattern, the unpredictable course and extreme variations in the manifestation of complications require an interdisciplinary treatment. Early diagnosis and initiation of an intensive lubricating and anti-inflammatory surface care are of utmost importance for the best visual outcome. This article is intended to help ophthalmologists towards a better understanding and interpretation of clinical signs of these conditions with the goal to achieve substantial improvements in visual outcome and of course the patient's quality of life

引用

页码：534 / 539

页数：6

共 41 条

[1] Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis - Results of an international prospective study [J].