A microfluidic chip for controlled release of drugs from microcapsules

被引：25

作者：

Cheng, Wen-Chuan ^{[1
]}

He, Yuan ^{[1
]}

Chang, An-Yi ^{[1
]}

Que, Long ^{[1
]}

机构：

[1] Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71272 USA

来源：

BIOMICROFLUIDICS | 2013年 / 7卷 / 06期

关键词：

HIGH-THROUGHPUT;

D O I：

10.1063/1.4829776

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new microfluidic device with liquid-droplet merging and droplet storage functions for the controlled release of drugs from microcapsules is reported. A switching channel is designed and integrated within the microfluidic device, facilitating the generation and capturing of uniform droplets by the storage chambers. The drug model is the MnCO3 microparticle, which is encapsulated by a microcapsule and fabricated using a simple layer-by-layer nanoassembly process. The merging function is used for dynamically adding the control solution into the droplets, which contain drugs within the microcapsules (DW mu Cs) and water. The storage chambers are used for collecting DW mu Cs-laden droplets so that the controlled-drug release in specific droplets can be monitored for an extended period of time, which has been experimentally implemented successfully. This technology could offer a promising technical platform for the long-term observation and studies of drug effects on specific cells in a controlled manner, which is especially useful for single cell analysis. (C) 2013 AIP Publishing LLC.

引用

页数：10

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