Photoinduced Three-Component Difluoroamidosulfonylation/Bicyclization: Regioselectivity Synthesis of Seven-Membered Dibenzosultams

被引：18

作者：

Zheng, Xiangyun ^{[1
]}

Shen, Qitao ^{[1
]}

Yin, Chuanliu ^{[1
]}

Li, Lianghao ^{[1
]}

Zhong, Tianshuo ^{[1
]}

Yu, Chuanming ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Photocatalyst-free; Three-component; Difluoroamidosulfonylation; Regioselectivity; Derivatization; SULFUR-DIOXIDE; BIOLOGICAL EVALUATION; CATALYZED SYNTHESIS; ANNULATION; ACCESS; CYCLIZATION; INSERTION; ALKYNES; ROUTE; AMINOSULFONYLATION;

D O I：

10.1002/adsc.202200292

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A mild and safe photochemical methodology has been developed to access difluoroamidosulfonylated dioxodibenzothiazepines via three-component radical bicyclization cascades. This photocatalyst-free transformation avoids cumbersome photocatalyst removal procedure and potential toxicity. Mechanistic experiments reveal the generation of an electron donor-acceptor (EDA) complex in the reaction process. Moreover, synthetic value of the protocol is further demonstrated by gram-scale reaction, conversion of product and total synthesis of antidepressant drug.

引用

页码：1750 / 1756

页数：7

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