Chromatin: The nucleosome unwrapped

被引：15
作者：
Widom, J [1 ]
机构：
[1] NORTHWESTERN UNIV,DEPT CHEM,EVANSTON,IL 60208
来源：
CURRENT BIOLOGY | 1997年 / 7卷 / 10期
关键词：
D O I：
10.1016/S0960-9822(06)00327-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structure of the nucleosome core particle has been determined by X-ray crystallography at 2.8 Angstrom resolution. The structure has several significant surprises, and provides important new insights into the structure and function of chromatin. (C) Current Biology Ltd ISSN 0960-9822.
引用
收藏
页码：R653 / R655
页数：3
相关论文
共 10 条
[1]   THE NUCLEOSOMAL CORE HISTONE OCTAMER AT 3.1-A RESOLUTION - A TRIPARTITE PROTEIN ASSEMBLY AND A LEFT-HANDED SUPERHELIX [J].
ARENTS, G ;
BURLINGAME, RW ;
WANG, BC ;
LOVE, WE ;
MOUDRIANAKIS, EN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :10148-10152
[2]   HISTONE H3 AND H4 N-TERMINI INTERACT WITH SIR3 AND SIR4 PROTEINS - A MOLECULAR-MODEL FOR THE FORMATION OF HETEROCHROMATIN IN YEAST [J].
HECHT, A ;
LAROCHE, T ;
STRAHLBOLSINGER, S ;
GASSER, SM ;
GRUNSTEIN, M .
CELL, 1995, 80 (04) :583-592
[3]  
Lowary PT, 1997, P NATL ACAD SCI USA, V94, P1183, DOI 10.1073/pnas.94.4.1183
[4]   Crystal structure of the nucleosome core particle at 2.8 angstrom resolution [J].
Luger, K ;
Mader, AW ;
Richmond, RK ;
Sargent, DF ;
Richmond, TJ .
NATURE, 1997, 389 (6648) :251-260
[5]   A model for the cooperative binding of eukaryotic regulatory proteins to nucleosomal target sites [J].
Polach, KJ ;
Widom, J .
JOURNAL OF MOLECULAR BIOLOGY, 1996, 258 (05) :800-812
[6]   Nucleosome transcription studied in a real-time synchronous system: Test of the lexosome model and direct measurement of effects due to histone octamer [J].
Protacio, RU ;
Widom, J .
JOURNAL OF MOLECULAR BIOLOGY, 1996, 256 (03) :458-472
[7]   STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 7A RESOLUTION [J].
RICHMOND, TJ ;
FINCH, JT ;
RUSHTON, B ;
RHODES, D ;
KLUG, A .
NATURE, 1984, 311 (5986) :532-537
[8]  
van Holde K. E., 1989, CHROMATIN
[9]   Chromatin: Histone acetyltransferases in control [J].
Wade, PA ;
Wolffe, AP .
CURRENT BIOLOGY, 1997, 7 (02) :R82-R84
[10]   TOWARD A UNIFIED MODEL OF CHROMATIN FOLDING [J].
WIDOM, J .
ANNUAL REVIEW OF BIOPHYSICS AND BIOPHYSICAL CHEMISTRY, 1989, 18 :365-395
1