Alum-Catalyzed Synthesis of 3-(1H-Pyrrol-2-yl)-2H-chromen-2-ones: A Water-PEG 400 Binary Solvent Mediated, One-Pot, Three-Component Protocol

被引：16

作者：

Pal, Gargi ^{[1
]}

Paul, Sanjay ^{[1
]}

Das, Asish R. ^{[1
]}

机构：

[1] Univ Calcutta, Dept Chem, Kolkata 700009, India

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 09期

关键词：

pyrrole derivatives; coumarin; alum; binary solvent; green protocol; POTENTIAL ANTIVIRAL AGENTS; REUSABLE CATALYST; COUMARIN DERIVATIVES; ANTIOXIDANT ACTIVITY; ACYCLIC DERIVATIVES; BIOLOGICAL-ACTIVITY; (ARYLOXYIMINO)ETHYLCOUMARINS; GLYCOSIDOPYRROLES; PYRROLES; ZNO;

D O I：

10.1055/s-0032-1318494

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, one-pot, three-component condensation reaction of 3-(bromoacetyl)coumarin, acetylacetone, and an amine using the inexpensive, environmentally benign, and mild catalyst alum as an efficient catalyst and the water-PEG 400 binary solvent system gives 3-(1-aryl-4-acetyl-5-methyl-1H-pyrrol-2-yl)-2H-chromen-2-ones, a new heterocyclic scaffold containing both the coumarin and pyrrole nuclei in a single molecule, in good to excellent yields. This methodology offers several advantages: simple procedure, excellent yields, short reaction times, and green aspects such as avoiding toxic catalysts and solvents.

引用

页码：1191 / 1200

页数：10

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